Original paper
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
Abstract
Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently unknown. Here, we show that, in cellular models of restriction endonuclease-induced mtDNA double-strand breaks, linear mtDNA is eliminated within hours by exonucleolytic activities. Inactivation of the mitochondrial...
Paper Details
Title
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
Published Date
Apr 30, 2018
Journal
Volume
9
Issue
1
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Notes
History