Distinct HLA associations of LGI1 and CASPR2-antibody diseases
Abstract
The recent biochemical distinction between antibodies against leucine-rich, glioma-inactivated-1 (LGI1), contactin-associated protein-2 (CASPR2) and intracellular epitopes of voltage-gated potassium-channels (VGKCs) demands aetiological explanations. Given established associations between human leucocyte antigen (HLA) alleles and adverse drug reactions, and our clinical observation of frequent adverse drugs reactions in patients with LGI1...
Paper Details
Title
Distinct HLA associations of LGI1 and CASPR2-antibody diseases
Published Date
May 18, 2018
Journal
Volume
141
Issue
8
Pages
2263 - 2271
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