Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models

Volume: 279, Pages: 292 - 305
Published: Jun 1, 2018
Abstract
Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased efficacy in clinical trials. A better understanding of how tumor heterogeneity affects nanoparticle accumulation could help elucidate this discrepancy and help in patient selection for nanomedicine therapy. Here we studied...
Paper Details
Title
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Published Date
Jun 1, 2018
Volume
279
Pages
292 - 305
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