Biomedical application and controlled drug release of electrospun fibrous materials.

Published on Sep 1, 2018in Materials Science and Engineering: C5.88
· DOI :10.1016/J.MSEC.2018.05.007
Huiling Cheng1
Estimated H-index: 1
(SDU: Shandong University),
Xiaoye Yang2
Estimated H-index: 2
(SDU: Shandong University)
+ 2 AuthorsGuangxi Zhai1
Estimated H-index: 1
(SDU: Shandong University)
Sources
Abstract
Abstract Electrospinning, as a nanotechnology, is able to produce polymeric fibers materials with nanoscale structure which are also named electrospun fibers material (EFM). These EFMs can be used in many biomedical applications such as wound dressing, tissue engineering, and medical textile materials. Over the last decades, electrospun nanofibers also have been applied to drug delivery such as orodispersible film, solid dispersion and various controlled release dosage forms due to many properties such as high surface to volume ratio, high porous, ease of fabrication and adaptability and so on. This review focuses on the recent advances in biomedical application of EFM, controlled drug release from EFM and devices for producing sophisticated EFM. The processing parameters which influence the physicochemical properties of the resulting EFM are also summarized as well as scaling up techniques for mass production of EFM.
📖 Papers frequently viewed together
4,038 Citations
465 Citations
20084.23Polymer
3 Authors (Seema Agarwal, ..., Andreas Greiner)
1,784 Citations
References155
Newest
#1Yonggang Xiang (HAU: Huazhong Agricultural University)H-Index: 3
#2Nwe Nwe Linn Oo (NTU: Nanyang Technological University)H-Index: 2
Last. Xian Jun Loh (Agency for Science, Technology and Research)H-Index: 68
view all 5 authors...
Sustained gene delivery is of particular importance today because it circumvents the need for repeated therapeutic administration and provides spatial and temporal control of the release profile. Better understanding of the genetic basis of diseases and advances in gene therapy have propelled significant research on biocompatible gene carriers for therapeutic purposes. Varied biodegradable polymer-based architectures have been used to create new compositions with unique properties suitable for s...
72 CitationsSource
#1Xiaoli Liu (UCPH: University of Copenhagen)H-Index: 4
#2Johanna Aho (UCPH: University of Copenhagen)H-Index: 15
Last. Mingshi Yang (UCPH: University of Copenhagen)H-Index: 28
view all 8 authors...
Abstract The aim of this study was to investigate the influence of polymer molecular structure on the electrospinnability and mechanical properties of electrospun fibrous mats (EFMs). Polymers with similar molecular weight but different composition ratios (lactic acid (LA) and glycolic acid (GA)) were dissolved in binary mixtures of N,N -dimethylformamide (DMF) and tetrahydrofuran (THF). The intrinsic viscosity and rheological properties of polymer solutions were investigated prior to electrospi...
5 CitationsSource
#1Marie Richard-Lacroix (UdeM: Université de Montréal)H-Index: 9
#2Christian Pellerin (UdeM: Université de Montréal)H-Index: 20
Abstract Electrospun fibers are complex polymeric materials with a typical diameter of a few hundred nanometers that are often frozen in out-of-equilibrium states due to the fast solvent evaporation and high elongational forces during the process. Their molecular orientation, and the parameters affecting it, is a critical (although challenging) parameter to characterize because it allows improving and tuning many properties. In this paper, we characterize molecular orientation of poly(ethylene o...
6 CitationsSource
#1Shuai LiH-Index: 2
#2Ruihua LvH-Index: 13
Last. Lin GeH-Index: 1
view all 6 authors...
In this article, we report the effects of the molecular weight on the electrospinnability of polylactide (PLA) solutions under identical conditions. Only above the entanglement concentration could uniform fibers be generated for PLA with a low molecular weight. However, electrospinning from a solution below its entanglement concentration produced uniform nanofibers when a high-molecular-weight PLA was adopted. The slow relaxation of high-molecular-weight PLA was expected to preserve chain interc...
5 CitationsSource
#1Lixia Zhu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Jinyue Dai (CAS: Chinese Academy of Sciences)H-Index: 18
Last. Jin Zhu (CAS: Chinese Academy of Sciences)H-Index: 26
view all 6 authors...
By covalently immobilizing imidazolium ion onto molecular chain, functional polyurethane (PU) is fabricated and thus an effective way is initiated to prepare electrospun membranes with antibacterial activity. In the experiment, PUs containing imidazolium ion side group (Bmim-PUs) are synthesized through a two-step polymerization process. It includes prepolymerization of isophorone diisocyanate (IPDI) with polyester glycol and chain extension polymerization using imidazolium-based ionic diol (Bmi...
12 CitationsSource
#1Abdurizzagh Khalf (OSU: Oklahoma State University–Stillwater)H-Index: 6
#2Sundararajan V. Madihally (OSU: Oklahoma State University–Stillwater)H-Index: 31
Abstract Electrospun fibers have seen an insurgence in biomedical applications due to their unique characteristics. Coaxial and triaxial electrospinning techniques have added new impetus via fabrication of multilayered nano and micro-size fibers. These techniques offer the possibility of forming fibers with features such as blending, reinforced core, porous and hollow structure. The unique fabrication process can be used to tailor the mechanical properties, biological properties and release of v...
98 CitationsSource
#1Hualin Wang (Hefei University of Technology)H-Index: 19
#2Lilan Hao (Hefei University of Technology)H-Index: 5
Last. Shaotong Jiang (Hefei University of Technology)H-Index: 25
view all 6 authors...
Abstract The aim of the present study was to evaluate the release kinetics and antibacterial activities of curcumin (CUR) loaded in zein (zein-CUR) electrospun fibers towards Escherichia coli ( E. coli , 8099) and Staphylococcus aureus ( S. aureus , ATCC 6538). CUR was successfully loaded in zein fibers by electrospinning technique, and the encapsulation efficiency was close to 100% and the encapsulated CUR still retained its antioxidant capacity. The morphology and size of fibers strongly depen...
95 CitationsSource
#1Sing Shy LiowH-Index: 21
#2Qingqing DouH-Index: 20
Last. Xian Jun Loh (NUS: National University of Singapore)H-Index: 68
view all 14 authors...
: A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window.
118 CitationsSource
#1Xiaoli Liu (UCPH: University of Copenhagen)H-Index: 4
#2Stefania Baldursdottir (UCPH: University of Copenhagen)H-Index: 16
Last. Mingshi Yang (SPU: Shenyang Pharmaceutical University)H-Index: 28
view all 7 authors...
Purpose In this study, the electrospinnability of poly(lactic-co-glycolic acid) (PLGA) solutions was investigated, with a focus on understanding the influence of molecular weight of PLGA, solvent type and solvent composition on the physical properties of electrospun nanofibers.
17 CitationsSource
#1Lucie Vysloužilová (Technical University of Liberec)H-Index: 6
#2Matej Buzgo (Charles University in Prague)H-Index: 12
Last. Evžen Amler (Charles University in Prague)H-Index: 16
view all 11 authors...
Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofiber...
31 CitationsSource
Cited By43
Newest
#1Andrea Dodero (UniGe: University of Genoa)H-Index: 9
#2Guy Schlatter (UDS: University of Strasbourg)H-Index: 23
Last. Maila Castellano (UniGe: University of Genoa)H-Index: 18
view all 5 authors...
Abstract The present review discusses the use of cyclodextrins and their derivatives to prepare electrospun nanofibers with specific features. Cyclodextrins, owing to their unique capability to form inclusion complexes with hydrophobic and volatile molecules, can indeed facilitate the encapsulation of bioactive compounds in electrospun nanofibers allowing fast-dissolving products for food, biomedical, and pharmaceutical purposes, filtering materials for wastewater and air purification, as well a...
1 CitationsSource
#1Xiaoxuan Deng (University of Otago)
#2Muhammad Qasim (University of Otago)H-Index: 33
Last. Azam Ali (University of Otago)H-Index: 9
view all 3 authors...
Sutures are the most popular surgical implants in the global surgical equipment market. They are used for holding tissues together to achieve wound closure. However, controlling the body's immune response to these "foreign bodies" at site of infection is challenging. Natural polymers such as collagen, silk, nylon, and cotton, and synthetic polymers such as polycaprolactone, poly(lactic-co-glycolic acid), poly(p-dioxanone) and so forth, contribute the robust foundation for the engineering of drug...
Source
#1Xiaolian Niu (TUT: Taiyuan University of Technology)H-Index: 1
#2Miao Qin (TUT: Taiyuan University of Technology)H-Index: 1
Last. Di Huang (TUT: Taiyuan University of Technology)H-Index: 8
view all 10 authors...
Polyamide-6 (PA6) is a synthetic polymer that bears resemblance to collagen in its backbone and has excellent stability in human body fluid. Chitosan (CS) with the similar structure to that of the polysaccharides existing in the extracellular matrix, has a more suitable biodegradation rate for the formation of new-bone. Eelectrospun fiber have nanoscale structure, high porosity and large specific surface area, can simulate the structure and biological function of the natural extracellular matrix...
Source
#1Xingzi Lan (GDUT: Guangdong University of Technology)H-Index: 4
#2Han Wang (GDUT: Guangdong University of Technology)H-Index: 12
Last. Yadong Tang (Wuyi University)H-Index: 2
view all 9 authors...
2 CitationsSource
Last. André F. MoreiraH-Index: 17
view all 4 authors...
Despite all the efforts that have been done up to now, the currently available wound dressings are still unable to fully re-establish all the structural and functional properties of the native skin. To overcome this situation, researchers from the tissue engineering area have been developing new wound dressings (hydrogels, films, sponges, membranes) aiming to mimic all the features of native skin. Among them, asymmetric membranes emerged as a promising solution since they reproduce both epiderma...
Source
#1Lan Ma (NU: Nanjing University)H-Index: 2
#2Yijun Yu (NU: Nanjing University)H-Index: 4
Last. Leiying Miao (NU: Nanjing University)H-Index: 6
view all 7 authors...
The repair of skeletal defects in maxillofacial region remains an intractable problem, the rising technology of bone tissue engineering provides a new strategy to solve it. Scaffolds, a crucial element of tissue engineering, must have favorable biocompatibility as well as osteoinductivity. In this study, we prepared berberine/polycaprolactone/collagen (BBR/PCL/COL) scaffolds with different concentrations of berberine (BBR) (25, 50, 75 and 100 μg/mL) through electrospinning. The influence of dosa...
Source
#1Aakanksha Ruhela (IITH: Indian Institute of Technology, Hyderabad)
#2Gokula Nathan Kasinathan (IITH: Indian Institute of Technology, Hyderabad)
Last. Chandra Shekhar Sharma (IITH: Indian Institute of Technology, Hyderabad)H-Index: 18
view all 5 authors...
Abstract One of the significant problems associated with islet encapsulation for type 1 diabetes treatment is the loss of islet functionality or cell death after transplantation because of the unfavorable environment for the cells. In this work, we propose a simple strategy to fabricate electrospun membranes that will provide a favorable environment for proper islet function and also a desirable pore size to cease cellular infiltration, protecting the encapsulated islet from immune cells. By ele...
Source
#1Vinod V.T. Padil (Technical University of Liberec)H-Index: 16
#2Jun Young Cheong (KAIST)H-Index: 17
Last. Rajender S. VarmaH-Index: 82
view all 10 authors...
Abstract Electrospinning has garnered significant attention in view of its many advantages such as feasibility for various polymers, scalability required for mass production, and ease of processing. Extensive studies have been devoted to the use of electrospinning to fabricate various electrospun nanofibers derived from carbohydrate gum polymers in combination with synthetic polymers and/or additives of inorganic or organic materials with gums. In view of the versatility and the widespread choic...
8 CitationsSource
#1Hoik Lee (KITECH)H-Index: 20
#1Hoik Lee (KITECH)H-Index: 4
Last. Daekyung SungH-Index: 4
view all 6 authors...
Source
#1Yuanlan Ning (Shaanxi University of Science and Technology)H-Index: 1
#2Wen Shen (Shaanxi University of Science and Technology)H-Index: 3
Last. Ao Fen (Shaanxi University of Science and Technology)H-Index: 1
view all 3 authors...
Source