Abstract null null To develop novel imprinted poly (methacrylic acid) nanoparticles for the controlled release of Rivastigmine Tartrate (RVS), the amalgamation of molecular imprinting techniques and polymerization of precipitates were applied in this work. By permuting different concentrations of pentaerythritol triacrylate (PETA) or trimethylolpropane triacrylate (TMPTA) as cross-linkers, ten different samples were synthesized, and their abilities assessed for RVS absorption. Among them, unifor...
Last. Aniruddha Roy(BITS: Birla Institute of Technology and Science)H-Index: 13
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Abstract null null The importance of the extra-cellular matrix (ECM) for wound healing has been extensively researched. Understanding its importance, multiple ECM mimetic scaffolds have been developed. However, the majority of such scaffolds are prefabricated. Due to their stiffness, prefabricated scaffolds cannot come into direct contact with the basal skin cells at the wound bed, limiting their efficacy. We have developed a unique wound dressing, using chitosan (CH) and chondroitin sulfate (CS...
Last. Lobat Tayebi(Marquette University)H-Index: 42
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Abstract null null Objectives null The aim of this work was to combine engineered hard and soft tissue, adopting a new method for interfacial adhesion of osteo-mucosal construct. We hypothesized that the chemical procedure involved in this method not only adheres the components, but also improves the cell growth inside them. null null null Methods null 3D-printed functionally-graded porous hard-tissue scaffolds were characterized, functionalized by aminolysis and tyrosinase, and accommodated by ...
Abstract null null Injectable self-healing hydrogels of natural polysaccharides that mimic the extracellular matrix to promote cellular growth are attractive materials for wound healing. Here, a novel hydrogel was fabricated based on carboxymethyl chitosan (CS) and aldehyde functionalized sodium alginate via Schiff base reaction. To enhance the hydrogel's properties, carboxymethyl-functionalized polymethyl methacrylate (PMAA) short nanofibers were obtained through sodium hydroxide-treated polyme...
#2Cibrán Mariño(University of Santiago de Compostela)
Last. Mariana Landin(University of Santiago de Compostela)H-Index: 25
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Abstract null null Numerous therapeutic strategies have been developed for osteoarthritis (OA) management, including intra-articular (IA) injections. The ideal IA formulation should control cartilage degradation and restore synovial fluid viscosity. To this end, we propose to combine thermo-sensitive polymers (poloxamers) with hyaluronic acid (HA) to develop suitable beta-lapachone (βLap) loaded IA formulations. The development of IA formulations with these components entails several difficultie...
#1Shan Fu(Northeastern University (China))H-Index: 4
#2Yuan Zhang(Northeastern University (China))H-Index: 2
Last. Erlin Zhang(Northeastern University (China))H-Index: 26
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Abstract null null The precipitates in null Ti-Ag alloy made an important contribution to antibacterial activity. In order to study this specific effects, null Ti-Ag samples with different forms of precipitates were produced by powder metallurgy and ingot metallurgy followed by heat treatment: Ti-Ag(T4) with no precipitate, Ti-Ag(as-cast) and Ti-Ag(T6) with Ti2Ag and Ti-Ag(PM) with Ti2Ag and Ag-rich phase. Microstructure was analyzed by scanning electronic microscope (SEM), and the antibacterial...
Abstract null null Hydrogel coatings can improve the biocompatibility of medical devices. However, stable surface bonding and homogeneity of hydrogel coatings are often challenging. This study exploits the benefits of biohybrid hydrogels of crosslinked four-armed poly(ethylene glycol) and heparin to enhance the hemocompatibility of cobalt‑chromium (CoCr) vascular stents. A bonding layer of dual silane and poly(ethylene-alt-maleic anhydride) (PEMA) treatment was applied to the stent to provide co...
Abstract null null Tendon being a hypocellular, low vascularized tissue often requires assistance for restoration after complete tear. Tendon tissue engineering aims in the development of suitable scaffold that could support the regeneration of tendon after damage. The success of such scaffolds is dependent on its integration with the native tissue which in turn is influenced by the cell-material interaction. In this work aligned poly(e-caprolactone)/collagen (PCL/collagen) multiscale fibers wer...
Abstract null null Alginate fibrous materials have been applied as wound dressing to enhance wound healing due to its nontoxic, biodegradable, and hemostatic nature. Conventional nonwoven fabrication tactics, however, showed weakness in inflammation, degradation stability and mechanical properties. Herein, the wet-spun alginate fibers were prepared by a novel wheel spinning technique, then knitted into wound dressing. Benefiting from optimized wet spinning parameters and the agglomeration of alg...
Abstract Seriously compromised function of some organs can only be restored by transplantation. Due to the shortage of human donors, the need to find another source of organs is of primary importance. Decellularized scaffolds of non-human origin are being studied as highly potential biomaterials for tissue engineering. Their biological nature and thus the ability to provide a naturally-derived environment for human cells to adhere and grow highlights their great advantage in comparison to synthe...