Glymphatic system

Operating system

Psychiatry

Circadian rhythm

Internal medicine

Endocrinology

Pathology

Psychology

Neuroscience

Sleep (system call)

Amyloid (mycology)

Human brain

Sleep deprivation

Disease

Cerebrospinal fluid

Amyloid β

Amyloid precursor protein

Computer science

Alzheimer's disease

Medicine

Proceedings of the National Academy of Sciences

Significance There has been an emerging interest in sleep and its association with β-amyloid burden as a risk factor for Alzheimer’s disease. Despite the evidence that acute sleep deprivation elevates β-amyloid levels in mouse interstitial fluid and in human cerebrospinal fluid, not much is known about the impact of sleep deprivation on β-amyloid burden in the human brain. Using positron emission tomography, here we show that acute sleep deprivation impacts β-amyloid burden in brain regions that have been implicated in Alzheimer’s disease. Our observations provide preliminary evidence for the negative effect of sleep deprivation on β-amyloid burden in the human brain.

β-Amyloid accumulation in the human brain after one night of sleep deprivation