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Revisiting the role of ABC transporters in multidrug-resistant cancer
Abstract
Most patients who die of cancer have disseminated disease that has become resistant to multiple therapeutic modalities. Ample evidence suggests that the expression of ATP-binding cassette (ABC) transporters, especially the multidrug resistance protein 1 (MDR1, also known as P-glycoprotein or P-gp), which is encoded by ABC subfamily B member 1 (ABCB1), can confer resistance to cytotoxic and targeted chemotherapy. However, the development of MDR1...
Paper Details
Title
Revisiting the role of ABC transporters in multidrug-resistant cancer
Published Date
Apr 11, 2018
Journal
Volume
18
Issue
7
Pages
452 - 464