Detection of anti‐platelet antibodies in immune thrombocytopenia by flow cytometry

Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterised by low platelet count (≤100 × 109/l), resulting from accelerated platelet destruction and/or impaired platelet production (Cines et al, 2009). Anti-platelet antibodies (APAbs) are detectable in ~60% of ITP patients, with glycoprotein Ib-IX and αIIbβ3 representing the major antigenic targets (Cooper, 2017). APAbs can promote platelet clearance and also diminish...