Perioperative Administration of Traditional Japanese Herbal Medicine Daikenchuto Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

Published on Nov 1, 2017in Anticancer Research1.994
· DOI :10.21873/ANTICANRES.12043
Mitsuru Ishizuka20
Estimated H-index: 20
(Dokkyo Medical University),
Norisuke Shibuya6
Estimated H-index: 6
(Dokkyo Medical University)
+ 5 AuthorsKeiichi Kubota (Dokkyo Medical University)
Sources
Abstract
AIM: Although it has been widely demonstrated that administration of Daikenchuto (DKT), a traditional Japanese herbal medicine, improves gastrointestinal (GI) motility in patients undergoing abdominal surgery, few studies have investigated the efficacy of perioperative DKT administration for relief of postoperative ileus (PI) in patients undergoing surgery for GI cancer. Therefore, the aim of this study was to investigate whether perioperative administration of DKT relieves PI in patients with GI cancer. PATIENTS AND METHODS: We performed a comprehensive electronic search of the literature (Cochrane Library, PubMed, the Web of Science and ICHUSHI) up to December 2016 to identify studies that had shown the efficacy of perioperative DKT administration for relief of PI in patients with GI cancer. To integrate the individual effect of DKT, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI), and heterogeneity was analyzed using I2 statistics. RESULTS: Seven studies involving a total of 1,134 patients who had undergone GI cancer surgery were included in this meta-analysis. Among 588 patients who received DKT perioperatively, 67 (11.4%) had PI, whereas among 546 patients who did not receive DKT perioperatively, 87 (15.9%) had PI. Perioperative administration of DKT significantly reduced the occurrence of PI (RR=0.58, 95% CI=0.35-0.97, p=0.04, I2=48%) in comparison to patients who did not receive DKT or received placebo. CONCLUSION: The result of this meta-analysis suggests that perioperative administration of DKT relieves PI in patients undergoing surgery for GI cancer.
📖 Papers frequently viewed together
4 Citations
5 Citations
4 Citations
References0
Newest
Cited By13
Newest
Source
#1Ichiro Arai (Nihon Pharmaceutical University)H-Index: 5
Background Japanese Kampo medicine is a traditional medicine with roots in ancient Chinese medicine. Because traditional physicians had been abolished in Japan, the present mainstream of Kampo treatment is that physicians who learned modern Western medicine prescribe Kampo extract products based on Western medical diagnosis. This situation is different from that in other east Asian countries, and the physicians require scientific clinical evidence. Methods Clinical studies were searched from lit...
Source
#1Kotaro Maeda (Fujita Health University)H-Index: 14
#2Hidetoshi Katsuno (Fujita Health University)H-Index: 11
Last. Toru KonoH-Index: 11
view all 3 authors...
Objectives This study aimed to elucidate the effect of the extract of daikenchuto (DKT), a Japanese Kampo medicine, on the contractile activity of the internal anal sphincter in conscious dogs. Methods Force transducers were attached to the serosal surface of the rectum and the internal anal sphincter of male beagle dogs. In addition, the contractile activity of the rectum and the internal anal sphincter was continuously measured until 6 h after DKT administration via telemetry in the conscious ...
Source
#1Toru Aoyama (YCU: Yokohama City University)H-Index: 25
#2Hiroshi Tamagawa (YCU: Yokohama City University)H-Index: 11
Kampo medicine or Japanese/Chinese traditional herbal medicine has long been used for the treatment of various diseases, mainly in Asian countries. In recent years, Asian investigators have attempted to clarify the mechanism and clinical efficacy of Kampo medicine. This review summarizes the background, current status, and future perspectives of Kampo medicine in the multimodal treatment of gastrointestinal cancer. Regarding the clinical effect of Kampo medicine on postoperative dysfunction afte...
1 CitationsSource
#1Fumie Oyama (Hirosaki University)H-Index: 1
#2Masayuki Futagami (Hirosaki University)H-Index: 15
Last. Yoshihito Yokoyama (Hirosaki University)H-Index: 27
view all 10 authors...
BACKGROUND: Postoperative ileus is a major complication of abdominal surgical procedures. The purpose of this study was to investigate preventive effect of daikenchuto (DKT) on onset of ileus in patients who received gynecological surgery for malignant tumors. METHODS: A total of 904 patients who received gynecological surgery for malignant tumors by opening retroperitoneum along with retroperitoneal lymph node dissection during a period between 2004 and 2018 were included in this retrospective ...
1 CitationsSource
#1Ryutaro Arita (Tohoku University)H-Index: 7
#2Takehiro Numata (Tohoku University)H-Index: 7
Last. Tadashi Ishii (Tohoku University)H-Index: 11
view all 11 authors...
A traditional Japanese medicine, daikenchuto (DKT), is used for treating abdominal bloating and pain with coldness. In modern medicine, it is used to treat postoperative intestinal dysfunction and ...
4 CitationsSource
#1David O. KennedyH-Index: 65
#2Emma L. WightmanH-Index: 10
Last. Philippa A. JacksonH-Index: 12
view all 5 authors...
Background: Zanthoxylum armatum DC. (ZA) is a traditional Asian culinary spice and medicinal compound, which is rich in monoterpenes and hydroxy α-sanshool. Mechanistic interactions with the monoamine, cholinergic and cannabinoid neurotransmission systems, as well as transient receptor potential (TRP) and potassium ion channels, may predispose ZA to modulate human brain function. Objectives: To investigate the effects of a single dose and 56-days supplementation with a lipid extract of ZA on cog...
6 CitationsSource
#1Kunitsugu Kubota (University of Tokushima)H-Index: 4
#2Akihito MaseH-Index: 5
Last. Mitsuo Shimada (University of Tokushima)H-Index: 92
view all 9 authors...
BACKGROUND: The traditional Japanese herbal medicine, daikenchuto (DKT), has been used to treat constipation and postoperative ileus. However, the precise mechanisms involved in the pharmacological effects of DKT remain uncertain. The aim of this study was to clarify the effect of DKT on motor patterns and transit activity in the isolated rat colon. METHODS: The entire colon or segments of the proximal colon in rats were isolated and placed in Krebs solution. The motility of the colon was evalua...
3 CitationsSource
#1Masayoshi Hosaka (Kyoto University)H-Index: 1
#2Ichiro Arai (Nihon Pharmaceutical University)H-Index: 5
Last. Yoshiharu Motoo (Kanazawa Medical University)H-Index: 37
view all 9 authors...
Background The Japan Society for Oriental Medicine makes a compilation of structured abstracts of randomized controlled trials (RCTs) of Kampo medicines available on its Evidence Reports of Kampo Treatment (EKAT) website.
5 CitationsSource
#1Toru KonoH-Index: 32
#2Mitsuo Shimada (University of Tokushima)H-Index: 92
Last. Masaki Kitajima (International University of Health and Welfare)H-Index: 19
view all 18 authors...
Purpose Prolonged postoperative ileus (POI) is a common complication after open abdominal surgery (OAS). Daikenchuto (DKT), a traditional Japanese medicine that peripherally stimulates the neurogenic pathway, is used to treat prolonged POI in Japan. To analyze whether DKT accelerates the recovery from prolonged POI after OAS, we conducted a secondary analysis of three multicenter randomized controlled trials (RCTs).
8 CitationsSource