Anticancer Research
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#1Apoorva Rao (UNSW: UNSW Sydney)
#2Jasmine J. Mui (UNSW: UNSW Sydney)
Last. David L. Morris (UNSW: UNSW Sydney)H-Index: 94
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BACKGROUND/AIM While controversial, cytoreductive surgery (CRS) with heated intra-peritoneal chemotherapy (HIPEC) and early postoperative intra-peritoneal chemotherapy (EPIC) remains the mainstay of treatment for low grade appendiceal neoplasm with pseudomyxoma peritonei (PMP). Our study aimed to investigate the difference in survival when administering HIPEC alone vs. HIPEC + EPIC. Additionally, we examined whether the duration of EPIC affects survival. PATIENTS AND METHODS We compared the diff...
#1Hiroaki KurodaH-Index: 19
#2Katsuhiro MasagoH-Index: 22
Last. Yasushi YatabeH-Index: 110
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BACKGROUND/AIM Circulating tumor cells (CTCs) is one of the promising markers that predict dissemination and metastases. This study aimed to identify the relationship between CTCs in pulmonary vein (PuV) and spread through air space (STAS) in non-small cell lung cancers. MATERIALS AND METHODS We applied a cytology-based microfluidic platform for rare cell isolation. Twenty-four patients were enrolled. RESULTS The rate of CTC detection in PuV was 79.2%, and STAS was observed in 54.2% of the sampl...
#1Jannica Meklin (UEF: University of Eastern Finland)H-Index: 2
#2Eskelinen M (UEF: University of Eastern Finland)H-Index: 16
Last. Matti Eskelinen (UEF: University of Eastern Finland)H-Index: 23
view all 7 authors...
BACKGROUND/AIM The present study compared the accuracy of visually analyzed (VA) and automatically analyzed (AA) ColonView (CV) quick test; a new-generation fecal immunochemical test (FIT) for hemoglobin (Hb) and hemoglobin/haptoglobin (Hb/Hp) (Biohit Oyj, Helsinki, Finland) in subjects participating in colorectal neoplasia (CRN) detection in Brazil. A traditional guaiac-based fecal occult blood test (gFOBT) test (HemoccultSENSA) was used as a reference. PATIENTS AND METHODS A cohort of 509 colo...
BACKGROUND/AIM Programmed death-ligand 1 (PD-L1) expression on tumor cells is a predictive biomarker of programmed cell death 1 (PD-1) blockade therapy. This study sought to clarify predictors of the efficacy of nivolumab in non-small cell lung cancer (NSCLC) patients with PD-L1 expression-negative tumors. PATIENTS AND METHODS We retrospectively reviewed the records of advanced NSCLC patients between January 2016 and April 2019, and investigated the predictive marker of nivolumab including the s...
#1Wafa BouleftourH-Index: 7
#2Benoîte MéryH-Index: 9
Last. Nicolas MagnéH-Index: 53
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Cardiotoxicity is a common side effect induced by cancer therapies, which increases the risk of long-term morbidity and mortality in cancer survivors. To date, the mechanism leading to this toxicity is still unclear, thus complicating cardiac safety assessment and predictive factor identification. The advances in technology, particularly regarding radiation therapy and constant development of novel antineoplastic agents, require urgent development of efficient preclinical models to detect drug c...
#1Shibutani Masatsune (OCU: Osaka City University)
#2Kenjiro Kimura (OCU: Osaka City University)H-Index: 20
Last. Masaichi Ohira (OCU: Osaka City University)H-Index: 43
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BACKGROUND/AIM The identification of risk factors for recurrence after resection of colorectal liver metastasis is necessary in order to establish a more effective treatment strategy. In addition to well-known prognostic factors, such as the tumor diameter and number of metastatic tumors, a large amount of intraoperative blood loss (IBL) and blood transfusion have recently been reported to be associated with shorter long-term survival. The aim of this study was to assess the impact of IBL and bl...
#1Masaya Takahashi (OCU: Osaka City University)H-Index: 5
#2Katsuyuki Takahashi (OCU: Osaka City University)H-Index: 13
Last. Katsuya Nagayama (OCU: Osaka City University)H-Index: 4
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BACKGROUND/AIM This study aimed to identify the predictive markers for carboplatin-induced severe thrombocytopenia. PATIENTS AND METHODS We conducted a retrospective cohort analysis of inpatients who received carboplatin and pemetrexed. RESULTS Among the 106 eligible patients, the incidence rate of grade ≥3 thrombocytopenia was 29.2% (31/106). Multivariate analysis revealed that grade ≥3 thrombocytopenia was associated with platelet count ≤26.6×104/mm3 [odds ratio (OR)=24.70, 95% confidence inte...
#1Michiyasu Ishizawa (Nihon University)H-Index: 10
#2Ayako Hirayu (Nihon University)
Last. Makoto Makishima (Nihon University)H-Index: 48
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BACKGROUND Zinc is a mineral that is essential for biological molecules, such as transcription factors, and is involved in the maintenance of intestinal homeostasis. Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] and is also important in intestinal functions, such as calcium absorption and epithelial barrier maintenance. However, the crosstalk between vitamin D signaling and zinc signaling in intestinal cells remains poorly unders...
#1Gianluca Vanni (University of Rome Tor Vergata)H-Index: 12
#2Marco Pellicciaro (University of Rome Tor Vergata)H-Index: 7
Last. Marco Materazzo (University of Rome Tor Vergata)H-Index: 9
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BACKGROUND/AIM Reduction of postoperative stress is a modern tenet in surgical oncology with the aim of reducing early postoperative lymphopenia. Our prospective study evaluated post-operative immune response at baseline and postoperative day (POD) 1 and 2 after direct-to-implant pre-pectoral (PP) breast reconstruction with titanium-coated polypropylene mesh versus subpectoral (SP) breast reconstruction. PATIENTS AND METHODS Between January and December 2020, 37 patients were randomized between ...
#1Yoshie Tsujiya (MWU: Mukogawa Women's University)
#2Motohiro Yamamori (MWU: Mukogawa Women's University)H-Index: 13
Last. Noboru Okamura (MWU: Mukogawa Women's University)H-Index: 25
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BACKGROUND/AIM This study aimed to assess the effects of telmisartan (TEL), a potential antitumor agent, and its mechanism of action in the regulation of apoptosis, autophagy, and cell cycle in scirrhous gastric cancer (SGC). MATERIALS AND METHODS The effect of TEL on the viability and chromatin condensation of OCUM-2M and OCUM-12 cells was assessed. Protein expression and the cell cycle were analysed using western blotting and flow cytometry, respectively. RESULTS TEL inhibited cell proliferati...
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