Anticancer Research
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#1Daniel StellerH-Index: 4
Last. Samer G. HakimH-Index: 17
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Background/aim null Side effects of zolendronic acid (ZA) and RANKL inhibitors (RANKL-I) include impaired wound healing and osteonecrosis of the jaw. Platelet rich fibrin (PRF) enhances wound healing and bone remodelling in vivo and in vitro. However, the topical use PRF in the surgical treatment of patients with medicament-related osteonecrosis of the jaw is relatively new and not thoroughly investigated. Furthermore, the potential attenuation of the PRF effect following antiresorptive treatmen...
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#1Kyosuke Agawa (Kobe University)
#2Kimihiro Yamashita (Kobe University)H-Index: 14
Last. Naoki Urakawa (Kobe University)H-Index: 6
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Background/aim null Cancer stem cells (CSCs) contribute to resistance against neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC). We conducted a retrospective observational study for the relationship between the expression levels of CSC markers in biopsy specimens prior to 5-fluorouracil plus cisplatin (FP)-NAC and the pathological responses. null Patients and methods null We included 171 patients with ESCC who underwent the FP-NAC followed by radical resection. Biopsy s...
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Background null Metastases of meningiomas are infrequent and the site of extracranial metastasis such as the bone is extremely rare. null Case report null A 75-year-old male had a history of five sessions of surgery and gamma-knife treatment for brain meningioma over a period of 29 years. He visited our hospital because he noticed a swelling in his anterior chest 2 years and 6 months after the final treatment. After an open biopsy, histopathological analysis revealed the mass to be a metastatic ...
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#1Tsai-Kun WuH-Index: 1
#2Yen-Chuan OuH-Index: 14
Last. Chia-Jen LeeH-Index: 1
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Background/aim null Cetyltrimethylammonium bromide (CTAB), a quaternary ammonium surfactant, was shown to have antitumor effects in a cellular mode of head and neck squamous cell carcinoma (HNSCC), modulating apoptotic and cytotoxic processes. However, the mechanisms by which CTAB exerts its effects against the epithelial- mesenchymal transition in HNSCC remain poorly understood. In the present study, we investigated whether CTAB inhibits cellular mobility and invasiveness of hypopharyngeal squa...
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#1Sayuri Hashimoto (Fukuoka University)
#2Masayoshi Nagai (Fukuoka University)H-Index: 1
Last. Toshiyuki Tsunoda (Fukuoka University)H-Index: 14
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Background/aim null Among compounds from natural products selectively suppressing the growth of cancer spheroids, which have mutant (mt) KRAS, NP910 was selected and its derivatives explored. null Materials and methods null The area of HKe3 spheroids expressing wild type (wt) KRAS (HKe3-wtKRAS) and mtKRAS (HKe3-mtKRAS) were measured in three-dimensional floating (3DF) cultures treated with 18 NP910 derivatives. The 50% cell growth inhibition (GI50) was determined by long-term 3DF (LT3DF) culture...
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#1Jomnarong Lertsuwan (Chulabhorn Research Institute)H-Index: 4
#2Jisnuson Svasti (Chulabhorn Research Institute)H-Index: 41
Last. Jutamaad Satayavivad (Chulabhorn Research Institute)H-Index: 24
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BACKGROUND/AIM Cholangiocarcinoma is a lethal disease with increasing incidence worldwide. New therapeutic compounds are urgently needed for this disease. Here, the inhibitory effect of adenosine on cholangiocarcinoma cells was studied. MATERIALS AND METHODS Western blot analysis was used to study autophagy and flow cytometry to analyze cell death and the cell cycle. RESULTS Cholangiocarcinoma and immortalized cholangiocytes responded to adenosine differently, and adenosine inhibited cholangioca...
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#1Fredrik Landström (Örebro University)H-Index: 6
#2Stefan Kristiansson (Örebro University)H-Index: 2
Last. Johan Reizenstein (Örebro University)H-Index: 11
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BACKGROUND/AIM Electrochemotherapy (ECT) is a cancer treatment modality where the efficacy of a chemotherapeutic agent is enhanced by an electrical field. It is an established palliative treatment for cutaneous metastases but its role in curative treatment remains mostly undetermined. Studies have previously reported that ECT can be a safe curative treatment in both skin cancer and oral cavity cancer. The primary aim of this case study was to report the long-term results of ECT in curative treat...
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#1Kunihiko Tokashiki (TMU: Tokyo Medical University)H-Index: 1
#2Isaku Okamoto (TMU: Tokyo Medical University)H-Index: 7
Last. Kiyoaki Tsukahara (TMU: Tokyo Medical University)H-Index: 16
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BACKGROUND/AIM This study evaluated the incidence of perioperative complications in jejunal flap compared with the free tissue flap approach. PATIENTS AND METHODS This study included 75 patients who underwent free flap reconstruction for hypopharyngeal carcinoma. The primary outcome was the incidence of pharyngocutaneous fistula, and the secondary outcomes were perioperative complications. RESULTS Pharyngocutaneous fistula developed in 7% of patients who underwent jejunal flap procedures and 6% ...
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#1Hiromitsu Watanabe (Hamamatsu University School of Medicine)H-Index: 4
#2Asuka Kawakami (Hamamatsu University School of Medicine)
Last. Hideaki Miyake (Hamamatsu University School of Medicine)H-Index: 56
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Background/aim null Cabazitaxel is known to be effective in patients with castration-resistant prostate cancer (CRPC) showing resistance to docetaxel. The objective of this study was to investigate the molecular mechanism mediating cytotoxic activity of cabazitaxel in docetaxel-resistant human CRPC cells. null Materials and methods null Parental human CRPC cell line PC3 (PC3/P) was continuously exposed to increasing doses of docetaxel, and a cell line resistant to docetaxel, PC3/R, was developed...
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#1Michiko Kubo-Kaneda (Mie University)H-Index: 1
#2Eiji Kondo (Mie University)H-Index: 10
Last. Tomoaki Ikeda (Mie University)H-Index: 36
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BACKGROUND/AIM This study aimed to compare laparoscopy with laparotomy and evaluate the effectiveness of a laparoscopic combined retroperitoneal and transperitoneal approach for para-aortic lymphadenectomy in patients with endometrial cancer. PATIENTS AND METHODS In this single-center retrospective study, patients with endometrial cancer who underwent para-aortic lymphadenectomy between December 2016 and November 2019 were analyzed. The patient's clinical and pathologic data were procured from m...
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