Histologic Criteria to Define Irritable Bowel Syndrome: Within the Realms of Possibility?

Boyer J, Saint-Paul MC, Dadone B, et al. Inflammatory cell distribution in colon mucosa as a new tool for diagnosis of irritable bowel syndrome: a promising pilot study. Neurogastroenterol Motil 2018;31(1). Clinicians are encouraged to make a positive diagnosis of irritable bowel syndrome (IBS) using symptom-based diagnostic criteria. However, not infrequently, the diagnosis is one of exclusion after invasive investigation, such as colonoscopy,...