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Original paper

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Volume: 115, Issue: 10, Pages: 2371 - 2376
Published: Feb 20, 2018
Abstract
Significance An understanding of the mechanisms by which viruses evade host immunity is essential to the development of antiviral drugs and viral detection strategies. Ubiquitin and ubiquitin-like modifications are crucial in cellular innate immune and infection responses and are often suppressed by viral proteins. We here identify a previously unknown mechanism of viral evasion. A viral protease, Lb pro , removes ubiquitin and the...
Paper Details
Title
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
Published Date
Feb 20, 2018
Volume
115
Issue
10
Pages
2371 - 2376
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