Original paper

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Volume: 115, Issue: 10, Pages: 2371 - 2376
Published: Feb 20, 2018
Abstract
In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here reveal that the leader protease, Lbpro, from foot-and-mouth disease virus (FMDV) targets ISG15 and to a lesser extent, ubiquitin in an unprecedented manner. Unlike canonical...
Paper Details
Title
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies
Published Date
Feb 20, 2018
Volume
115
Issue
10
Pages
2371 - 2376
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