A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets

Volume: 215, Issue: 3, Pages: 761 - 771
Published: Jan 26, 2018
Abstract
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering mutations or chromosome translocations, with major implications for oncogenic transformation. However, understanding the specificity of AID has proved extremely challenging. We have sequenced at very high depth >1,500 genomic...
Paper Details
Title
A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
Published Date
Jan 26, 2018
Volume
215
Issue
3
Pages
761 - 771
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