Inhibition of yes‐associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model

Yes‐associated protein ( YAP ) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine model. We found that metastatic NSCLC cell lines H2030‐BrM3(K‐ras G12C mutation) and PC 9‐BrM3 ( EGFR Δexon19 mutation) had a significantly decreased p‐ YAP (S127)/ YAP ratio compared to parental...