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Original paper

PARP-1–Targeted Radiotherapy in Mouse Models of Glioblastoma

Volume: 59, Issue: 8, Pages: 1225 - 1233
Published: Mar 23, 2018
Abstract
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damage and apoptosis in cancer cells, while sparing healthy brain tissue. Methods: We synthesized an 131I-labeled PARP-1 therapeutic and...
Paper Details
Title
PARP-1–Targeted Radiotherapy in Mouse Models of Glioblastoma
Published Date
Mar 23, 2018
Volume
59
Issue
8
Pages
1225 - 1233
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