Effects of Huang Bai (Phellodendri Cortex) on bone growth and pubertal development in adolescent female rats

To evaluate the effects of Huang Bai (Phellodendron amurense) on growth and maturation in adolescent female rats. Female Sprague–Dawley rats (28 days old; n = 72) were divided into six daily treatment groups: control (distilled water), Huang Bai (100 and 300 mg/kg), recombinant human GH (rhGH; 20 μg/kg), estradiol (1 μg/kg), and triptorelin (100 μg). Body weight, food intake, and vaginal opening were measured daily from postnatal day (PND) 28 to...