Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions

Essentials Neutrophil extracellular traps (NETs) are generated during thrombosis and sepsis. The effect of hemodynamics on NETosis during sterile thrombosis was studied using microfluidics. Pressure gradients > 70 mmHg per mm-clot across sterile occlusions drive shear-induced NETosis. High interstitial hemodynamic forces trigger rapid NET release.Background Neutrophil extracellular traps (NETs) are released when neutrophils encounter infectious...