Subchondral Trabecular Rod Loss and Plate Thickening in the Development of Osteoarthritis

Developing effective treatment for osteoarthritis (OA), a prevalent and disabling disease, has remained a challenge, primarily because of limited understanding of its pathogenesis and late diagnosis. In the subchondral bone, rapid bone loss after traumatic injuries and bone sclerosis at the advanced stage of OA are well‐recognized hallmarks of the disease. Recent studies have further demonstrated the crucial contribution of subchondral bone in...