Original paper
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Abstract
Treatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet to be validated in large cohorts. By analyzing longitudinal tumor biopsies from 17 metastatic melanoma patients treated with CPB therapies, we observed point mutations, deletions or loss of...
Paper Details
Title
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Published Date
Oct 26, 2017
Journal
Volume
8
Issue
1
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Notes
History