Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78
Abstract
Inhibition of tumour angiogenesis has an important role in antitumour therapy. However, a recent study indicates that antiangiogenesis therapy may lead to glucose-related protein 78 (GRP78) associated antiapoptotic resistance. The present study aims to elucidate the dual effects of plasminogen kringle 5 (K5) on tumour angiogenesis and apoptosis induction by targeting hypoxia-inducible factor 1 α (HIF-1 α ) and GRP78. Co-immunoprecipitation and...
Paper Details
Title
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78
Published Date
Oct 26, 2017
Journal
Volume
8
Issue
10
Pages
e3144 - e3144
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