Cell Death and Disease
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8.47
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7,522
Papers 7,324
1 page of 733 pages (7,324 results)
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#1Jianke Lv (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)
#2Qianqian Shi (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)
Last. Renyong Zhi (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)
view all 14 authors...
Invasive micropapillary carcinoma (IMPC) is a special histological subtype of breast cancer, featured with extremely high rates of lymphovascular invasion and lymph node metastasis. Based on a previous series of studies, our team proposed the hypothesis of "clustered metastasis of IMPC tumor cells". However, the transcriptomics characteristics underlying its metastasis are unknown, especially in spatial transcriptomics (ST). In this paper, we perform ST sequencing on four freshly frozen IMPC sam...
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#1Qingjie Fan (Dalian Medical University)H-Index: 3
#2Yuanhang Wu (Dalian Medical University)
Last. Wenzhe Li (Dalian Medical University)H-Index: 14
view all 11 authors...
Vaginal dysbiosis often occurs in patients with cervical cancer. The fucosylation of mucosal epithelial cells is closely related to microbial colonization, and play an important role in protecting the vaginal mucosal epithelial cells. However, no reports on the relationship between vaginal dysbiosis and abnormal mucosal epithelial cell fucosylation, and their roles in the occurrence and development of cervical cancer are unavailable. Here we report that core fucosylation levels were significantl...
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#1Feng-Ze Sun (Sun Yat-sen University)H-Index: 1
#2Yuan-Yuan Liu (Sun Yat-sen University)
Last. Mengjia Song (Sun Yat-sen University)H-Index: 5
view all 21 authors...
Most patients with hepatocellular carcinoma (HCC) are in the middle or advanced stage at the time of diagnosis, and the therapeutic effect is limited. Therefore, this study aimed to verify whether deoxythymidylate kinase (DTYMK) increased in HCC and was an effective therapeutic target in HCC. The findings revealed that the DTYMK level significantly increased and correlated with poor prognosis in HCC. However, nothing else is known, except that DTYMK could catalyze the phosphorylation of deoxythy...
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#1Simone Carotti (UCBM: Università Campus Bio-Medico)H-Index: 19
#2Daniele Lettieri-Barbato (University of Rome Tor Vergata)H-Index: 11
Last. Maria Francesconi (UCBM: Università Campus Bio-Medico)H-Index: 4
view all 19 authors...
Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro and in vivo models of fat overload and in NAFLD patients. LAL protein content and activity were firstly evaluated in Huh7 cells exposed to high-glucose/high-lipid (HGHL) medium and in the liver of C57BL/6 mice fed with high-fat diet (HFD) for 4 and 8 months. LAL protein was also evaluated ...
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#1Yi-Hsiang Wang (NHRI: National Health Research Institutes)
#2Chia-Yi Shen (NTHU: National Tsing Hua University)
Last. Lu-Hai Wang (NHRI: National Health Research Institutes)H-Index: 7
view all 9 authors...
Certain immune cells and inflammatory cytokines are essential components in the tumor microenvironment to promote breast cancer progression. To identify key immune players in the tumor microenvironment, we applied highly invasive MDA-MB-231 breast cancer cell lines to co-culture with human monocyte THP-1 cells and identified CXCL7 by cytokine array as one of the increasingly secreted cytokines by THP-1 cells. Further investigations indicated that upon co-culturing, breast cancer cells secreted C...
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#1Jun T. Low (WEHI: Walter and Eliza Hall Institute of Medical Research)
#1JT Low (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 3
Last. John Silke (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 82
view all 14 authors...
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#1Huizhen Wang (SMU: Southern Medical University)H-Index: 2
#2Yifan Wang (SMU: Southern Medical University)
Last. Aiqing Li (SMU: Southern Medical University)
view all 7 authors...
Phosphatase and Tensin Homolog on chromosome Ten (PTEN) has emerged as a key protein that governs the response to kidney injury. Notably, renal adaptive repair is important for preventing acute kidney injury (AKI) to chronic kidney disease (CKD) transition. To test the role of PTEN in renal repair after acute injury, we constructed a mouse model that overexpresses PTEN in renal proximal tubular cells (RPTC) by crossing PTENfl-stop-fl mice with Ggt1-Cre mice. Mass spectrometry-based proteomics wa...
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#1Jianyong Zhuo (ZJU: Zhejiang University)H-Index: 8
#2Di Lu (ZJU: Zhejiang University)H-Index: 13
Last. Zhengxing Lian (ZJU: Zhejiang University)H-Index: 2
view all 17 authors...
Cytokeratin 19-positive (CK19+) hepatocellular carcinoma (HCC) is an aggressive subtype characterized by early recurrence and chemotherapy tolerance. However, there is no specific therapeutic option for CK19+ HCC. The correlation between tumor recurrence and expression status of CK19 were studied in 206 patients undergoing liver transplantation for HCC. CK19-/+ HCC cells were isolated to screen effective antitumor drugs. The therapeutic effects of regorafenib were evaluated in patient-derived xe...
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#1Suhong Zhang (University of Minnesota)H-Index: 1
#2Haiting Dai (University of Minnesota)H-Index: 1
Last. Yiming Xing (University of Minnesota)H-Index: 1
view all 9 authors...
Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes and allows cell-cell and cell-environment communication. Dysregulation of TMEMs has been observed in multiple cancers. However, little is known about TMEM116 in cancer development. In this study, we demonstrate that TMEM116 is highly expressed in non-small-cell lung cancer (NSCLC) tissues and cell lines. Inactivation of TMEM116 reduced cell proliferation, migration and invasiveness of human cancer cells and supp...
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#1Dan-Ya Wu (HZAU: Huazhong Agricultural University)H-Index: 4
#2Xinxin Li (HZAU: Huazhong Agricultural University)H-Index: 1
Last. Bingbing Luo (HZAU: Huazhong Agricultural University)
view all 14 authors...
Nuclear transfer embryonic stem cells (ntESCs) hold enormous promise for individual-specific regenerative medicine. However, the chromatin states of ntESCs remain poorly characterized. In this study, we employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and three-dimensional (3D) genome organization of ntESCs. The results show that the chromatin accessibility and genome structures of somatic cells are re-arranged to ESC-like states overall in ntESCs, including compartme...
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