Cell Death and Disease
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#1Lin Chen (Southern Medical University)H-Index: 5
#2Guangjin Luo (Southern Medical University)H-Index: 3
Last. Donghong Hu (Southern Medical University)H-Index: 1
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It has been reported that growth differentiation factor 11 (GDF11) protects against myocardial ischemia/reperfusion (IR) injury, but the underlying mechanisms have not been fully clarified. Considering that GDF11 plays a role in the aging/rejuvenation process and that aging is associated with telomere shortening and cardiac dysfunction, we hypothesized that GDF11 might protect against IR injury by activating telomerase. Human plasma GDF11 levels were significantly lower in acute coronary syndrom...
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#1Keren Chen (SYSU: Sun Yat-sen University)H-Index: 3
#2Junyan Zhang (SYSU: Sun Yat-sen University)H-Index: 1
Last. Delin Mo (SYSU: Sun Yat-sen University)H-Index: 18
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High-mobility group box 2 (HMGB2) is an abundant, chromatin-associated protein that plays an essential role in the regulation of transcription, cell proliferation, differentiation, and tumorigenesis. However, the underlying mechanism of HMGB2 in adipogenesis remains poorly known. Here, we provide evidence that HMGB2 deficiency in preadipocytes impedes adipogenesis, while overexpression of HMGB2 increases the potential for adipogenic differentiation. Besides, depletion of HMGB2 in vivo caused the...
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#1Irina V. Saltykova (UAB: University of Alabama at Birmingham)
#2Asif Elahi (UAB: University of Alabama at Birmingham)
Last. Marina S. Gorbatyuk (UAB: University of Alabama at Birmingham)H-Index: 22
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Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/mTOR signaling in rd16 retinas, in which we restored the AKT/mTOR axis by genetic ablation of pseudokinase TRB3, known to inhibit phosphorylation of AKT and mTOR. First, we found that TRB3 ablation resulted in preservation of photoreceptor function in degenera...
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#1Jianjiao Ni (Fudan University)H-Index: 1
#2Xiaofei Zhang (Fudan University)H-Index: 1
Last. Liang Liu (Fudan University)H-Index: 2
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Bone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival and quality of life. Osteolytic BoM is characterised by aberrant differentiation and malfunction of osteoclasts through modulation of the TGF-β/pTHrP/RANKL signalling pathway, but its upstream regulatory mechanism is unclear. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from the peripheral blood of NSCLC ...
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#1Ye Zhu (YZU: Yangzhou University)H-Index: 3
#2Jia YouH-Index: 1
Last. Xiang Gu (YZU: Yangzhou University)H-Index: 2
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Long non-coding RNA (lncRNA) is receiving increasing attention in embryonic stem cells (ESCs) research. However, the roles of lncRNA in the differentiation of ESCs into pacemaker-like cells are still unclear. Therefore, the present study aims to explore the roles and mechanisms of lncRNA in the differentiation of ESCs into pacemaker-like cells. ESCs were cultured and induced differentiation to pacemaker-like cells. RNA sequencing was used to identify the differential expression lncRNAs during th...
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#1Yingchen Zhou (PKU: Peking University)
#2Longhua Ou (SZU: Shenzhen University)
Last. Yan Wang (PKU: Peking University)H-Index: 17
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Endocrine therapy for prostate cancer (PCa) mainly inhibits androgen receptor (AR) signaling, due to increased androgen synthesis and AR changes, PCa evolved into castration-resistant prostate cancer (CRPC). The function of Family With Sequence Similarity 64 Member A (FAM64A) and its association with prostate cancer has not been reported. In our research, we first reported that FAM64A is up-regulated and positively associated with poor prognosis of patients with prostate cancer (PCa) by TCGA dat...
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#1Yu-Chen Wang (Fudan University)H-Index: 3
#2Jie Wu (Fudan University)H-Index: 2
Last. Dingwei Ye (Fudan University)H-Index: 29
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Bladder cancer is one of the most common malignant tumors in the urinary system. The development and improvement of treatment efficiency require the deepening of the understanding of its molecular mechanism. This study investigated the role of ALPK2, which is rarely studied in malignant tumors, in the development of bladder cancer. Our results showed the upregulation of ALPK2 in bladder cancer, and data mining of TCGA database showed the association between ALPK2 and pathological parameters of p...
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#1Jun Wang (UAB: University of Alabama at Birmingham)
#2Holly R. Thomas (UAB: University of Alabama at Birmingham)H-Index: 6
Last. John M. Parant (UAB: University of Alabama at Birmingham)H-Index: 17
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Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream transcriptional apoptotic target genes (PUMA/BBC3 and NOXA/PMAIP1) have been implicated as mediators of stress signals. To evaluate the importance of key stress response components in vivo, we have generated zebrafish null alleles in puma, noxa, p53, p63, and p73. Utilizing these genetic mutants, we have deciphered that the apoptotic response to genotoxic...
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#1Andrew R. Hall (UCL: University College London)H-Index: 30
#2Niall Burke (UCL: University College London)H-Index: 8
Last. Derek J. Hausenloy (UCL: University College London)H-Index: 97
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#1Yuqian Zhu (SJTU: Shanghai Jiao Tong University)
#2Dandan Song (SJTU: Shanghai Jiao Tong University)
Last. Chunkang Chang (SJTU: Shanghai Jiao Tong University)H-Index: 15
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Mutations in the U2 small nuclear RNA auxiliary factor 1 (U2AF1) gene are the common feature of a major subset in myelodysplastic syndromes (MDS). However, the genetic landscape and molecular pathogenesis of oncogenic U2AF1S34F mutation in MDS are not totally understood. We performed comprehensive analysis for prognostic significance of U2AF1 mutations in acute myeloid leukemia (AML) cohort based on The Cancer Genome Atlas (TCGA) database. Functional analysis of U2AF1S34F mutation was performed ...
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Top fields of study
Molecular biology
Chemistry
Apoptosis
Programmed cell death
Cancer research
Biology
Cell biology