Pathophysiology of Gastroesophageal Reflux Disease
Abstract
The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinant of disease severity. This exposure arises via compromise of the anti-reflux barrier and reduced ability of the esophagus to...
Paper Details
Title
Pathophysiology of Gastroesophageal Reflux Disease
Published Date
Jan 1, 2018
Journal
Volume
154
Issue
2
Pages
277 - 288
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Notes
History