The conception of the ABCD study: From substance use to a broad NIH collaboration

Published on Oct 10, 2017in Developmental Cognitive Neuroscience4.966
· DOI :10.1016/J.DCN.2017.10.002
Nora D. Volkow183
Estimated H-index: 183
(NIDA: National Institute on Drug Abuse),
George F. Koob196
Estimated H-index: 196
(NIH: National Institutes of Health)
+ 19 AuthorsSusan R. B. Weiss13
Estimated H-index: 13
(NIDA: National Institute on Drug Abuse)
Sources
Abstract
Abstract Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.
📖 Papers frequently viewed together
374 Citations
4,556 Citations
1,766 Citations
References9
Newest
#1Hugh Garavan (UVM: University of Vermont)H-Index: 89
#2Hauke Bartsch (UCSD: University of California, San Diego)H-Index: 27
Last. D. Zahs (UM: University of Michigan)H-Index: 1
view all 10 authors...
Abstract The ABCD study is a new and ongoing project of very substantial size and scale involving 21 data acquisition sites. It aims to recruit 11,500 children and follow them for ten years with extensive assessments at multiple timepoints. To deliver on its potential to adequately describe adolescent development, it is essential that it adopt recruitment procedures that are efficient and effective and will yield a sample that reflects the nation’s diversity in an epidemiologically informed mann...
173 CitationsSource
#1Lloyd D. JohnstonH-Index: 118
#2Patrick M. O'MalleyH-Index: 129
Last. John E. SchulenbergH-Index: 114
view all 5 authors...
119 Citations
#1Terry L. Jernigan (UCSD: University of California, San Diego)H-Index: 101
#2Timothy T. Brown (UCSD: University of California, San Diego)H-Index: 34
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 27 authors...
The main objective of the multi-site Pediatric Imaging, Neurocognition, and Genetics (PING) study was to create a large repository of standardized measurements of behavioral and imaging phenotypes accompanied by whole genome genotyping acquired from typically-developing children varying widely in age (3 to 20 years). This cross-sectional study produced sharable data from 1493 children, and these data have been described in several publications focusing on brain and cognitive development. Researc...
167 CitationsSource
#1Sandra A. Brown (UCSD: University of California, San Diego)H-Index: 6
#2Ty Brumback (UCSD: University of California, San Diego)H-Index: 15
Last. Susan F. Tapert (UCSD: University of California, San Diego)H-Index: 88
view all 21 authors...
OBJECTIVE: During adolescence, neurobiological maturation occurs concurrently with social and interpersonal changes, including the initiation of alcohol and other substance use. The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) is designed to disentangle the complex relationships between onset, escalation, and desistance of alcohol use and changes in neurocognitive functioning and neuromaturation. METHOD: A sample of 831 youth, ages 12-21 years, was recruited at fiv...
99 CitationsSource
#1D. C. Van Essen (WashU: Washington University in St. Louis)H-Index: 41
#2Kamil Ugurbil (UMN: University of Minnesota)H-Index: 133
Last. Essa Yacoub (UMN: University of Minnesota)H-Index: 69
view all 26 authors...
The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subjects (twins and their non-twin siblings) using multiple imaging modalities along with extensive behavioral and genetic data. The imaging modalities will include diffusion imaging (dMRI), resting-state ...
1,266 CitationsSource
#1Karen M. Barlow (U of C: University of Calgary)H-Index: 27
#2Susan CrawfordH-Index: 39
Last. Deborah DeweyH-Index: 46
view all 6 authors...
Background: Much disagreement exists as to whether postconcussion syndrome (PCS) is attributable to brain injury or to other factors such as trauma alone, preexisting psychosocial problems, or medicolegal issues. We investigated the epidemiology and natural history of PCS symptoms in a large cohort of children with a mild traumatic brain injury (mTBI) and compared them with children with an extracranial injury (ECI). Methods: This investigation was a prospective, consecutive controlled-cohort st...
484 CitationsSource
#1Mark FaulH-Index: 26
#2Marlena M. WaldH-Index: 19
Last. Victor G. CoronadoH-Index: 32
view all 4 authors...
2,245 Citations
#1Leah H. Somerville (Cornell University)H-Index: 41
#2Rebecca M. Jones (Cornell University)H-Index: 27
Last. B. J. Casey (Cornell University)H-Index: 107
view all 3 authors...
Adolescence is a developmental period that entails substantial changes in affective and incentive-seeking behavior relative to both childhood and adulthood, including a heightened propensity to engage in risky behaviors and experience persistent negative and labile mood states. This review discusses the emotional and incentive-driven behavioral changes in adolescents and their associated neural mechanisms, focusing on the dynamic interactions between the amygdala, ventral striatum, and prefronta...
867 CitationsSource
The English language literature on the epidemiology of dual diagnosis is reviewed. The literature shows mental disorders to be significantly related to alcohol and drug use disorders. The strongest associations involve externalizing mental disorders and alcohol-drug dependence. Mental disorders are associated with alcohol-drug use, problems among users, dependence among problem users, and persistence among people with lifetime dependence. These dual diagnoses are associated with severity and per...
634 CitationsSource
Cited By173
Newest
#1Natania A. CraneH-Index: 17
Last. Robin J. MermelsteinH-Index: 61
view all 3 authors...
Abstract Introduction Alcohol, nicotine, and marijuana are the three most widely used substances among adolescents and young adults, with co-use of multiple substances being common. Few longitudinal studies have examined risk factors of alcohol, marijuana, and nicotine poly-substance use. We examined frequency of alcohol, marijuana, and cigarette poly-substance use over time and how key risk factors contribute to this substance use during adolescence and young adulthood. Methods Participants (N=...
Source
#1Xiaowei Song (NIDA: National Institute on Drug Abuse)H-Index: 4
#2Pamela Garcia-Saldivar (UNAM: National Autonomous University of Mexico)H-Index: 3
Last. Colline Poirier (Newcastle University)H-Index: 19
view all 12 authors...
Abstract Longitudinal non-human primate neuroimaging has the potential to greatly enhance our understanding of primate brain structure and function. Here we describe its specific strengths, compared to both cross-sectional non-human primate neuroimaging and longitudinal human neuroimaging, but also its associated challenges. We elaborate on factors guiding the use of different analytical tools, subject-specific versus age-specific templates for analyses, and issues related to statistical power.
Source
#1Anthony Steven Dick (FIU: Florida International University)H-Index: 21
#2Daniel A Lopez (URMC: University of Rochester Medical Center)H-Index: 2
Last. Andrew T. Marshall (SC: University of Southern California)H-Index: 14
view all 0 authors...
Abstract null null The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, e...
3 CitationsSource
#1Sadie J. Zacharek (MIT: Massachusetts Institute of Technology)
#2Sahana Kribakaran (Yale University)H-Index: 2
Last. Dylan G. Gee (Yale University)H-Index: 32
view all 0 authors...
Abstract null null Anxiety disorders are the most prevalent psychiatric condition among youth, with symptoms commonly emerging prior to or during adolescence. Delineating neurodevelopmental trajectories associated with anxiety disorders is important for understanding the pathophysiology of pediatric anxiety and for early risk identification. While a growing literature has yielded valuable insights into the nature of brain structure and function in pediatric anxiety, progress has been limited by ...
Source
#1Alexander S. Hatoum (WashU: Washington University in St. Louis)H-Index: 8
#2Emma C. Johnson (WashU: Washington University in St. Louis)H-Index: 10
Last. Ryan Bogdan (WashU: Washington University in St. Louis)H-Index: 37
view all 0 authors...
BACKGROUND AND AIMS Brain imaging-derived structural correlates of alcohol involvement have largely been speculated to arise as a consequence of alcohol exposure. However, they may also reflect predispositional risk. METHODS In substance naive children of European ancestry who completed the baseline session of the Adolescent Brain Cognitive Development (ABCD) Study (n=3,013), mixed-effects models estimated whether polygenic risk scores (PRS) for Problematic Alcohol Use (PAU-PRS) and Drinks Per W...
Source
#1Johanna Bayer (University of Melbourne)H-Index: 2
#2Richard Dinga (Radboud University Nijmegen)H-Index: 11
Last. Andre F. Marquand (Radboud University Nijmegen)H-Index: 44
view all 0 authors...
The potential of normative modeling to make individualized predictions from neuroimaging data has enabled inferences that go beyond the case-control approach. However, site effects are often confounded with variables of interest in a complex manner and can bias estimates of normative models, which has impeded the application of normative models to large multi-site neuroimaging data sets. In this study, we suggest accommodating for these site effects by including them as random effects in a hiera...
2 CitationsSource
#1Gareth Harman (OHSU: Oregon Health & Science University)H-Index: 3
#2Dakota Kliamovich (OHSU: Oregon Health & Science University)H-Index: 1
Last. Bonnie J. Nagel (OHSU: Oregon Health & Science University)H-Index: 50
view all 9 authors...
The objective of the current study was to build predictive models for suicidal ideation in a sample of children aged 9-10 using features previously implicated in risk among older adolescent and adult populations. This case-control analysis utilized baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study, collected from 21 research sites across the United States (N = 11,369). Several regression and ensemble learning models were compared on their ability to classify individu...
Source
#1Shervin AssariH-Index: 64
#2Shanika BoyceH-Index: 10
view all 3 authors...
AIM This study tested sex differences in the association between hippocampal volume and working memory of a national sample of 9-10-year-old children in the US. As the hippocampus is functionally lateralized (especially in task-related activities), we explored the results for the right and the left hippocampus. METHODS This is a cross-sectional study using the Adolescent Brain Cognitive Development (ABCD) Study data. This analysis included baseline ABCD data (n = 10,093) of children between ages...
Source
#1Brian FianiH-Index: 7
view all 7 authors...
Source
#1David E. Warren (UNMC: University of Nebraska Medical Center)H-Index: 20
#2Anthony Rangel (UNMC: University of Nebraska Medical Center)
Last. Tony W. Wilson (UNMC: University of Nebraska Medical Center)H-Index: 30
view all 11 authors...
The hippocampus is necessary for declarative (relational) memory, and the ability to form hippocampal-dependent memories develops through late adolescence. This developmental trajectory of hippocampal-dependent memory could reflect maturation of intrinsic functional brain networks, but resting-state functional connectivity (rs-FC) of the human hippocampus is not well-characterized for periadolescent children. Measuring hippocampal rs-FC in periadolescence would thus fill a gap, and testing covar...
Source