Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice

Essentials Plasmin is able to proteolyse von Willebrand factor. It was unclear if plasmin influences acute thrombotic thrombocytopenic purpura (TTP). Plasmin levels are increased during acute TTP though suppressed via plasmin(ogen) inhibitors. Allowing amplified endogenous plasmin activity in mice results in resolution of TTP signs.Background Thrombotic thrombocytopenic purpura (TTP) is an acute life-threatening pathology, caused by occlusive...