Contribution of Common SNPs to Variability in Late Radiation Therapy Toxicity in Prostate Cancer

Late toxicities following prostate cancer RT are dose-limiting and negatively affect quality of life. Inter-individual variability in the development of these toxicities is partly due to genetics. Several single nucleotide polymorphisms (SNPs) have been identified, but have modest effect sizes, so larger studies are needed to identify further associations. Also, it is not known whether the genetic contribution to late toxicities is mainly from...