Sarah L. Kerns
University of Rochester
Genome-wide association studyMachine learningCancerInternal medicineSNPPathologyOncologySingle-nucleotide polymorphismArtificial intelligenceOdds ratioRadiogenomicsGenetic associationRadiosensitivityTesticular cancerProstate cancerPopulationToxicityCisplatin based chemotherapyRadiation therapyBreast cancerBioinformaticsComputational biologyMedicineBiologyMeta-analysis
107Publications
27H-index
2,339Citations
Publications 97
Newest
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
#1Nicola Rares Franco (Ghent University Hospital)
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
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#1David V. Conti (SC: University of Southern California)H-Index: 72
#2Burcu F. Darst (SC: University of Southern California)H-Index: 18
Last. Christopher A. Haiman (SC: University of Southern California)H-Index: 113
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In the version of this article originally published, the names of the equally contributing authors and jointly supervising authors were switched. The correct affiliations are: “These authors contributed equally: David V. Conti, Burcu F. Darst. These authors jointly supervised this work: David V. Conti, Rosalind A. Eeles, Zsofia Kote-Jarai, Christopher A. Haiman.” The error has been corrected in the HTML and PDF versions of the article.
1 CitationsSource
#1David V. Conti (SC: University of Southern California)H-Index: 72
#2Burcu F. Darst (SC: University of Southern California)H-Index: 18
Last. Christopher A. Haiman (SC: University of Southern California)H-Index: 113
view all 231 authors...
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence...
7 CitationsSource
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#1Michela Carlotta Massi (Polytechnic University of Milan)H-Index: 2
#2Francesca Gasperoni (University of Cambridge)H-Index: 1
Last. Tiziana RancatiH-Index: 27
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Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this project was to analyse a cohort of patients recruited into REQUITE using a deep learning algorithm to identify patient-specific features associated with the development of toxicity, and test the approach by attempting to validate previously published genetic risk factors....
2 CitationsSource
#1Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
#2Chunkit Fung (URMC: University of Rochester Medical Center)H-Index: 22
Last. Lois B. Travis (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 40
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Background Few data exist on the relationship of cisplatin-related adverse health outcomes (AHOs) with disability, unemployment, and self-reported health (SRH) among testicular cancer survivors (TCS). Methods A total of 1815 TCS at least 1 year postchemotherapy underwent clinical examination and completed questionnaires. Treatment data were abstracted from medical records. A cumulative burden of morbidity score (CBMPt) encompassed the number and severity of platinum-related AHOs (peripheral sens...
2 CitationsSource
#1Brian Marples (URMC: University of Rochester Medical Center)H-Index: 9
#2Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
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#1John Kang (URMC: University of Rochester Medical Center)H-Index: 8
#2James Coates (University of Oxford)H-Index: 8
Last. Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
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: Machine learning (ML) provides a broad framework for addressing high-dimensional prediction problems in classification and regression. While ML is often applied for imaging problems in medical physics, there are many efforts to apply these principles to biological data toward questions of radiation biology. Here, we provide a review of radiogenomics modeling frameworks and efforts toward genomically guided radiotherapy. We first discuss medical oncology efforts to develop precision biomarkers....
5 CitationsSource
#1Kayla Collado (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
#2Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
Last. Barry S. Rosenstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 34
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Abstract Introduction A genetic test predicting susceptibility for the development of toxicities following prostate cancer radiotherapy is in development. This test intends to help physicians with treatment decision-making. Methods Radiation oncologists were surveyed using a web-based questionnaire to gauge their interest in using a genetic test predictive of increased risk of radiotherapy toxicities as an aid in determining therapy for men with prostate cancer. Responses were summarized using f...
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#1Sarah L. Kerns (URMC: University of Rochester Medical Center)H-Index: 27
#2Laura FachalH-Index: 24
Last. Catharine M L West (MAHSC: Manchester Academic Health Science Centre)H-Index: 77
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BACKGROUND: 10-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. METHODS: We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3,871) in men with European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequenc...
23 CitationsSource