Original paper
Structural basis of the redox switches in the NAD + -reducing soluble [NiFe]-hydrogenase
Abstract
NAD+ (oxidized form of NAD:nicotinamide adenine dinucleotide)-reducing soluble [NiFe]-hydrogenase (SH) is phylogenetically related to NADH (reduced form of NAD+):quinone oxidoreductase (complex I), but the geometrical arrangements of the subunits and Fe-S clusters are unclear. Here, we describe the crystal structures of SH in the oxidized and reduced states. The cluster arrangement is similar to that of complex I, but the subunits orientation is...
Paper Details
Title
Structural basis of the redox switches in the NAD + -reducing soluble [NiFe]-hydrogenase
Published Date
Aug 31, 2017
Journal
Volume
357
Issue
6354
Pages
928 - 932