Original paper
Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity
Volume: 117, Issue: 35, Pages: 21288 - 21298
Published: Aug 17, 2020
Abstract
Significance Selenoprotein N (SEPN1) is a type II transmembrane protein of the endoplasmic reticulum (ER) that senses luminal calcium through an EF-hand domain. On calcium depletion, a SEPN1 oligomer, prevalent under basal calcium concentrations, dissociates to generate a monomeric polypeptide that has enhanced redox trapping potential for its target the calcium pump, SERCA2, as well as for many additional interactors, indicating enhanced...
Paper Details
Title
Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity
Published Date
Aug 17, 2020
Volume
117
Issue
35
Pages
21288 - 21298