Old age causes de novo intracortical bone remodeling and porosity in mice
Abstract
Decreased cortical thickness and increased cortical porosity are the key anatomic changes responsible for osteoporotic fractures in elderly women and men. The cellular basis of these changes is unbalanced endosteal and intracortical osteonal remodeling by the osteoclasts and osteoblasts that comprise the basic multicellular units (BMUs). Like humans, mice lose cortical bone with age, but unlike humans, this loss occurs in the face of sex steroid...
Paper Details
Title
Old age causes de novo intracortical bone remodeling and porosity in mice
Published Date
Sep 7, 2017
Journal
Volume
2
Issue
17
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