Last. Magnus Simrén(UNC: University of North Carolina at Chapel Hill)H-Index: 21
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SummaryBackground Current subgrouping of Irritable Bowel Syndrome (IBS) is exclusively based on stool consistency without considering other relevant gastrointestinal (GI), extraintestinal somatic or psychological features. Aim To identify subgroups based on a comprehensive set of IBS-related parameters. Methods Mixture model analysis was used, with the following input variables: 13 single-item scores from the IBS-specific Gastrointestinal Symptom Rating Scale, average stool consistency and frequ...
#1C. Hookway(National Institute for Health and Care Excellence)H-Index: 4
#2Sara Buckner(National Institute for Health and Care Excellence)H-Index: 2
Last. D Longson(Manchester Mental Health and Social Care Trust)H-Index: 7
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#### The bottom line Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder with an estimated prevalence of 10-20%.1 The condition mostly affects people aged 20-30 years and is twice as common in women as in men.1 It can be painful and debilitating, lead to feelings of anxiety and depression, and negatively affect quality of life.1 This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) on irritable bowel syndrome i...
SummaryBackground Psychological factors may influence persistence and perceived severity of symptoms in irritable bowel syndrome (IBS). Literature suggests that somatisation is associated with IBS. However, the relationship between IBS subtype, symptoms of IBS and somatisation is unclear. Aim To examine this issue in a large cohort of secondary care patients. Methods Demographic and gastrointestinal (GI) symptom data were collected from 4224 adult patients via the Rome III questionnaire. Somatis...
Last. Paul Moayyedi(McMaster University)H-Index: 115
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Summary Background There is some evidence that, despite attempts to classify them separately, functional bowel disorders are not distinct entities and that such divisions are artificial. Aim To examine this issue in a large cohort of secondary care patients. Methods Consecutive, unselected adults with gastrointestinal (GI) symptoms attending out-patient clinics at two hospitals in Hamilton, Ontario were recruited. Demographic data, symptoms and presence of anxiety, depression or somatisation wer...
OBJECTIVE: Our objective was to review and compare, with meta-analytic methods, observational studies on the association of medically unexplained physical symptoms, anxiety, and depression with special emphasis on healthy and organically ill control groups and on different types of symptoms, measures, and illness behavior. METHODS: A search of MEDLINE and PsycLIT/PsycINFO for abstracts from 1980 to April 2001 was performed; principal investigators in the field were contacted and article referenc...
OBJECTIVE: Somatization is prevalent in primary care and is associated with substantial functional impairment and healthcare utilization. However, instruments for identifying and monitoring somatic symptoms are few in number and not widely used. Therefore, we examined the validity of a brief measure of the severity of somatic symptoms. METHODS: The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-15 compr...
ABSTRACT– A self-assessment scale has been developed and found to be a reliable instrument for detecting states of depression and anxiety in the setting of an hospital medical outpatient clinic. The anxiety and depressive subscales are also valid measures of severity of the emotional disorder. It is suggested that the introduction of the scales into general hospital practice would facilitate the large task of detection and management of emotional disorder in patients under investigation and trea...
INTRODUCTION: Conventionally, patients with irritable bowel syndrome (IBS) are subgrouped based on their predominant bowel habit. Given the relevance of psychological comorbidity to IBS symptoms, our aim was to explore an alternative approach to subgrouping by incorporating factors beyond stool form and frequency. METHODS: We collected demographic, symptom, and psychological health data from 1,375 adult subjects in the community who self-identified as having IBS, identifying 2 cohorts meeting ei...
#2Peter Friberg(University of Gothenburg)H-Index: 63
Last. Magnus Simrén(UNC: University of North Carolina at Chapel Hill)H-Index: 21
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Background: Disturbed brain-gut interactions are assumed to be of importance for symptom generation in patients with irritable bowel syndrome (IBS). The autonomic nervous system (ANS) is part of the bidirectional brain-gut communication, but previous studies in IBS show diverging results. We aimed to identify subgroups of IBS patients with distinct ANS characteristics differentiating them from healthy controls (HC), and to study associations between ANS status and symptoms. Methods: Heart rate v...