Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro

Sirimal Premakumara Galbada Arachchige; Walimuni Prabhashini Kaushalya Mendis Abeysekera; Wanigasekara Daya Ratnasooriya

doi:10.1155/2017/5076029

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Original Paper

Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro

,Walimuni Prabhashini Kaushalya Mendis Abeysekera,

Jan 1, 2017

Published

Abstract

Ethanol (95%) and dichloromethane : methanol (DCM : M, 1 : 1 v/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin- (BSA-) glucose and BSA-methylglyoxal models in vitro . Further, total proanthocyanidins (TP) were quantified. Results showed significant differences (p<0.05) between bark and leaf extracts for the studied biological activities (except antiglucosidase) and TP. BEs showed significantly high (p<0.05) activities for antiamylase (IC 50 : 214±2–215±10 μ g/mL), antibutyrylcholinesterase (IC 50 : 26.62±1.66–36.09±0.83 μ g/mL), and glycation reversing in BSA-glucose model (EC 50 : 94.33±1.81–<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M8"><mml:mn fontstyle="italic">107.16</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="...

Paper Details

Title: Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro
DOI: 10.1155/2017/5076029
Published: Jan 1, 2017
Journal
Volume: 2017
Issue: 1
Pages: 5076029–5076029