In metastatic breast cancer (mBC), the change of human epidermal growth factor receptor 2 (HER2) status between primary and metastatic lesions is widely recognized, however clinical implications are unknown. Our study address the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. Data of patients affected by HER2-positive mBC, treated with pertuzumab and/or trastuzumab-emtansine (T-DM1) in a real-world setting at 45 Italian cancer centers were retrospectively collected and analyzed. From 2003 to 2017, 491 HER2-positive mBC patients were included. Of these, 102 (20.7%) had been initially diagnosed as HER2-negative early BC. Estrogen and/or progesterone receptor were more expressed in patients with HER2-discordance compared to patients with HER2-concordant status (p < 0.0001 and p = 0.006, respectively). HER2-discordant tumors were characterized also by a lower rate of brain metastases (p = 0.01) and a longer disease free interval (p < 0.0001). Median overall survival was longer, although not statistically significant, in the subgroup of patients with HER2-discordant cancer with respect to patients with HER2-concordant status (140 vs 78 months, p = 0.07). Our findings suggest that patients with HER2-positive mBC with discordant HER2 status in early BC may have different clinical, biological and prognostic behavior compared to HER2-concordant patients.
Last. Xiaojia Wang(CAS: Chinese Academy of Sciences)H-Index: 6
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Background: Hormone receptor (HR) and human epidermal growth factor receptor (HER2) discordance between primary and metastatic breast cancer lesions is common. However, its impact on long-term survival remains unclear. We aimed to determine the prognostic value of this discordance in patients with metastaticf breast cancer (MBC). Methods: A total of 270 patients with MBC who were underwent re-biopsy of progressive metastases at Zhejiang Cancer Hospital from January 1, 2012 to December 31, 2015 w...
Background: In metastatic breast cancer, hormone and/or human epidermal growth factor receptor 2 (HER2)-targeted therapy decision-making is still largely based on tissue characteristics of the primary tumor. However, a change of estrogen receptor alpha (ERa), progesterone receptor (PR), and HER2 status in distant metastases has frequently been reported. The actual incidence of this phenomenon has been debated. Methods: We performed a meta-analysis including 39 studies assessing receptor conversi...
Last. John W. Park(UCSF: University of California, San Francisco)H-Index: 72
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Recent technological advancements in rare cell analysis have facilitated the detection of circulating tumor cells (CTCs) in the blood of patients diagnosed with breast and other types of cancers. Numerous clinical studies involving the enumeration of CTCs in breast cancer patients have unequivocally demonstrated the prognostic value of these cells. Evidence from recent molecular studies indicates that CTCs may be potential surrogate markers for systemic disease. As such, real-time assessment of ...
Background The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progression might help to optimize treatment decisions. In this context, characterization of circulating tumor cells (CTCs) could be of relevance since metastatic tissue may be difficult to obtain for repeated analysis. Here we compared HER2/ER/PR expression profiles of primary tumors, me...
#1C. Yeung(U of O: University of Ottawa)H-Index: 1
#2John Hilton(Ottawa Hospital Research Institute)H-Index: 22
Last. Angel Arnaout(Ottawa Hospital Research Institute)H-Index: 15
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Discordance in estrogen (ER), progesterone (PR), and HER2/neu status between primary breast tumours and metastatic disease is well recognized. In this review, we highlight how receptor discordance between primary tumours and paired metastasis can help elucidate the mechanism of metastasis but can also effect patient management and the design of future trials. Discordance rates and ranges were available from 47 studies (3384 matched primary and metastatic pairs) reporting ER, PR, and HER2/neu exp...
Last. Lyndsay Harris(Case Western Reserve University)H-Index: 31
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Purpose To provide recommendations on the appropriate use of breast tumor biomarker assay results to guide decisions on systemic therapy for metastatic breast cancer.
Background Enumeration of circulating tumor cells (CTCs) obtained from minimally invasive blood samples has been well established as a valuable monitoring tool in metastatic and early breast cancer, as well as in several other cancer types. The gold standard technology for detecting CTCs in blood against a backdrop of millions of leukocytes is the FDA-approved CellSearch system (Janssen Diagnostics), which relies on EpCAM-based immunomagnetic separation. Secondary characterization of these cells...
Last. Jonas Bergh(KI: Karolinska Institutet)H-Index: 97
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Background: Emerging data indicate an important role for biopsies of clinically/radiologically defined breast cancer 'recurrences'. The present study investigates tumour related events (relapses, other malignancies, benign conditions) after a primary breast cancer diagnosis. Patients and methods: The cohort includes 2102 women, representing all patients, with primary invasive breast cancer during 2000-2011 in the county of Varmland, Sweden. A comparative analysis of oestrogen receptor (ER), prog...
Last. Franco Nolè(IEO: European Institute of Oncology)H-Index: 47
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Abstract Background The discordance in oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) status between primary and recurrent breast cancer is being intensively investigated and a large amount of data have been produced. However, results from different studies are heterogeneous and often conflicting. To highlight this issue, a meta-analysis of published data was performed. Methods A literature search was performed using Medline, and all the ...
Last. Grzegorz Lisak(NTU: Nanyang Technological University)H-Index: 24
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Nickel nanoparticles (NiNPs) supported on activated multi-walled carbon nanotubes (MWCNTs) were used as an adsorbent applied towards Pb(II), As(V) and Cd(II) remediation from industrial wastewater. The result revealed the hydrophilic surface of MWCNTs-KOH was enhanced with the incorporation of NiNPs enabling higher surface area, functional groups and pore distribution. Comparatively, the removal of Pb(II), As(V) and Cd(II) on the various adsorbents was reported as NiNPs (58.6 ± 4.1, 46.8 ± 3.7 a...
Bifidobacteria are widely used as a probiotic for their health-promoting effects. To promote their growth, bifidogenic prebiotics, including human milk oligosaccharides (HMOs), have been added to supplements and infant formula. However, the efficacy of both probiotic and prebiotic interventions is often debated, as clinical responses vary significantly by case. Here, we review clinical studies that aimed to proliferate human-residential Bifidobacterium (HRB) strains in the gut, and we highlight ...
#1Adam Grzywaczyk(PUT: Poznań University of Technology)H-Index: 2
#2Wojciech Smułek(PUT: Poznań University of Technology)H-Index: 11
Last. Ewa Kaczorek(PUT: Poznań University of Technology)H-Index: 20
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Abstract null null Threats connected with contamination of environment with heavy metals include negative influence on human and animal health and also negatively influence the biodiversity of ecosystems. While applying various techniques of heavy metal remediation from soils, an important problem is the adsorption of ions on solid particles. In this respect, the composition and properties of soil strongly affect the efficiency of the process. Therefore, the aim of this study was to determine th...
Abstract null null Thorough understanding of the behaviour of core-shell microparticles with a liquid core is essential for determining their performance in applications under different operation conditions. This paper reports the behaviour of core-shell particles with a liquid core under thermal and mechanical loads. First, we formulated an analytical model for the heating process of a core-shell microparticle with a liquid core. Next, we utilised an axisymmetric model of an elastic spherical s...
Last. Leonardo Borghi(UFRJ: Federal University of Rio de Janeiro)H-Index: 11
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Abstract The Aptian Crato Member of the Araripe Basin is a 50-m-thick succession of laminated limestones alternated with siliciclastic rocks. This unit has been receiving attention worldwide mainly because it is one of the most famous fossil Konservat-Lagerstatten, where were identified well-preserved paleofauna and paleoflora. Clay mineralogy and lithogeochemical data have been widely used in paleoenvironmental, paleoclimatic and provenance reconstructions. However, these techniques were not sy...
Abstract null null In this work, the optimization of temperature, argon gas flow rate, acetylene gas flow rate and time effect on the yield of as-synthesized multi-wall carbon nanotubes (AS-MWCNTs) using a novel iron-nickel/biochar catalyst was investigated. Subsequently, the AS-MWCNTs was functionalized to oxidized multi-wall carbon nanotubes (OX-MWCNTs). The nanoadsorbents were applied for Cu(II) and Zn(II) ions adsorption from wastewater in a batch and fixed-bed process. Remarkably, the resul...
Last. Cristina Rueda(University of Valladolid)H-Index: 11
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This paper analyses COVID-19 patients' dynamics during the first wave in the region of Castilla y Leon (Spain) with around 2.4 million inhabitants using multi-state competing risk survival models. From the date registered as the start of the clinical process, it is assumed that a patient can progress through three intermediate states until reaching an absorbing state of recovery or death. Demographic characteristics, epidemiological factors such as the time of infection and previous vaccinations...
#2Mahnaz Habibi(IAU: Islamic Azad University)H-Index: 5
Last. Golnaz Taheri(KTH: Royal Institute of Technology)H-Index: 3
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Coronavirus disease 2019 (COVID-19) is caused by a novel virus named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus induced a large number of deaths and millions of confirmed cases worldwide, creating a serious danger to public health. However, there are no specific therapies or drugs available for COVID-19 treatment. While new drug discovery is a long process, repurposing available drugs for COVID-19 can help recognize treatments with known clinical profiles. Computati...
#2Ifrah Nabi Khan(GCUF: Government College University, Faisalabad)
Last. Yasser Shahzad(CUI: COMSATS Institute of Information Technology)H-Index: 12
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Background/Objective Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis. Methods Films were synthesized by double solvent casting tech...
