The Role of Gonadotropin-Releasing Hormone in Cancer Cell Proliferation and Metastasis

Expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors of the urogenital tract, including cancers of the ovary, endometrium, urinary bladder, and prostate. In addition, in breast cancers and in some cancers of non-reproductive tissues, including pancreatic cancers and glioblastoma, GnRH receptor expression was found. Dose- and...