Frontiers in Endocrinology
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#1Max E. Green (Mayo Clinic)
#2Victor Bernet (Mayo Clinic)H-Index: 19
Last. Joseph Cheung (Mayo Clinic)H-Index: 22
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Thyroid disorders and sleep disorders are common problems in the general population that can affect people of all ages, backgrounds, and sexes, but little is known about their clinical associations. We reviewed the literature assessing the associations between thyroid disease and sleep disorders and noted that hyperthyroidism and hypothyroidism have clinical overlap with sleep conditions such as insomnia, restless legs syndrome, and obstructive sleep apnea. These findings highlight the importanc...
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#1Kaio Cezar Rodrigues Salum (FIOCRUZ: Oswaldo Cruz Foundation)
#2Jônatas de Mendonça Rolando (Federal Fluminense University)
Last. Ana Carolina Proença da Fonseca (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 4
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Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition to obesogenic environmental factors, besides genetic susceptibility. In the past two decades, advances in genetic research identified variants of leptin-melanocortin pathway coding genes, which are related to the potentiation of satiety and hunger, immune system, and fertility. In this review, we listed the cases of congenital leptin deficiency and the beneficial effects of leptin replacement therapy av...
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#1Xuehan LuH-Index: 1
#2Lili HuangH-Index: 11
Last. Chen ChenH-Index: 116
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#2Yu LanH-Index: 3
Last. Yukun LuoH-Index: 14
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#1Angela Cristina de Nicola (UNESP: Sao Paulo State University)H-Index: 2
#2Larissa Brazoloto Ferreira (UNESP: Sao Paulo State University)
Last. Rita Cássia Menegati Dornelles (UNESP: Sao Paulo State University)H-Index: 13
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The important involvement of the suprachiasmatic nucleus (SCN) and the activity of vasopressinergic neurons in maintaining the rhythmicity of the female reproductive system depends on the mRNA transcription-translation feedback loops. Therefore, circadian clock function, like most physiological processes, is involved in the events that determine reproductive aging. This study describes the change of mRNA expression of clock genes, Per2, Bmal1, and Rev-erbα, in the hypothalamus-pituitary-gonadal ...
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#1Camila Oliveira de Souza (UTSW: University of Texas Southwestern Medical Center)
#2Xuenan Sun (UTSW: University of Texas Southwestern Medical Center)
Last. Da Young Oh (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
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Seven transmembrane receptors (7TMRs), often termed G protein-coupled receptors (GPCRs), are the most common target of therapeutic drugs used today. Many studies suggest that distinct members of the GPCR superfamily represent potential targets for the treatment of various metabolic disorders including obesity and type 2 diabetes (T2D). GPCRs typically activate different classes of heterotrimeric G proteins, which can be subgrouped into four major functional types: Gαs, Gαi, Gαq/11, and G12/13, i...
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#1Xin Zhao (Shanxi Medical University)
#2Minghe Wang (Shanxi Medical University)
Last. Yi Zhang (Shanxi Medical University)H-Index: 5
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Glucagon like peptide-1 (GLP-1) is an incretin secretory molecule. GLP-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes (T2DM) due to their attributes such as body weight loss, protection of islet β cells, promotion of islet β cell proliferation and minimal side effects. Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving he...
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#1Muhammad Rahmad Royan (NMBU: Norwegian University of Life Sciences)H-Index: 2
#2Siddique K (NMBU: Norwegian University of Life Sciences)
Last. Romain Fontaine (NMBU: Norwegian University of Life Sciences)H-Index: 11
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In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes via the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and comprehensive knowledge of the spatial distribution of those endocrine cell types is required to better understand their physiological functions. Using medaka as a model and several combinations of multi-color fluorescence in situ hybridization, we present the first 3D atlas reve...
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#1Juan Chen (SEU: Southeast University)H-Index: 3
#2Hong Sun (Soochow University (Suzhou))
Last. Zilin Sun (SEU: Southeast University)H-Index: 16
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Background: To compare the efficacy of lipid accumulation product (LAP) and urine glucose excretion (UGE) in predicting diabetes and evaluate whether the combination of LAP and UGE would help to improve the efficacy of using LAP alone or UGE alone in identifying diabetes. Methods: Data from 7485 individuals without prior history of diabetes who participated in a cross-sectional survey in Jiangsu, China, were analyzed. Each participant underwent an oral glucose-tolerance test. Operating character...
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#1Fangyuan Li (PKU: Peking University)
#2Ruihui Lu (PKU: Peking University)
Last. Qing Xue (PKU: Peking University)H-Index: 14
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Backgrounds Despite the great advances in assisted reproductive technology (ART), poor ovarian response (POR) is still one of the most challenging tasks in reproductive medicine. This predictive model we developed aims to predict the individual probability of clinical pregnancy failure for poor ovarian responders (PORs) under in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods The nomogram was developed in 281 patients with POR according to the Bologna criteria from Janua...
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Top fields of study
Endocrinology
Receptor
Diabetes mellitus
Hormone
Medicine
Biology
Cell biology