Abstract 1747: A microenvironment gene signature predicts poor outcome in patients with luminal breast cancers subjected to local-regional treatment

Gene expression studies, mainly addressed at the tumor cell compartment of breast cancers (BC) contributed to unravel the molecular heterogeneity providing clinicians with new and reliable tools for therapeutic planning. Despite many investigations have focused on genetic abnormalities initiating and driving tumorigenesis, there is now evidence that the cancer cell behavior depends not only on intrinsic features, but also on the interactions...