Maria Grazia Daidone
University of Milan
CancerInternal medicinePathologyOncologyCellMolecular biologyApoptosisImmunologyChemotherapyMammary glandCancer researchBreast cancerBioinformaticsCirculating tumor cellCell growthMedicineCell cultureEstrogen receptorBiologyTelomerase
351Publications
72H-index
15.1kCitations
Publications 346
Newest
#1Carolina ReduzziH-Index: 6
#2Serena Di CosimoH-Index: 31
Last. Vera CappellettiH-Index: 22
view all 16 authors...
The clinical relevance of circulating tumor cell clusters (CTC-clusters) in breast cancer (BC) has been mostly studied using the CellSearch®, a marker-dependent method detecting only epithelial-enriched clusters. However, due to epithelial-to-mesenchymal transition, resorting to marker-independent approaches can improve CTC-cluster detection. Blood samples collected from healthy donors and spiked-in with tumor mammospheres, or from BC patients, were processed for CTC-cluster detection with 3 tec...
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#1Marco SilvestriH-Index: 4
#2Carolina ReduzziH-Index: 6
Last. Vera CappellettiH-Index: 22
view all 15 authors...
Circulating tumor microemboli (CTMs) are clusters of cancer cells detached from solid tumors, whose study can reveal mechanisms underlying metastatization. As they frequently comprise unknown fractions of leukocytes, the analysis of copy number alterations (CNAs) is challenging. To address this, we titrated known numbers of leukocytes into cancer cells (MDA-MB-453 and MDA-MB-36, displaying high and low DNA content, respectively) generating tumor fractions from 0–100%. After low-pass sequencing, ...
1 CitationsSource
#2Arianna MicaliH-Index: 1
Last. Mariangela FiginiH-Index: 26
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Since the beginning of the COVID-19 outbreak, Cancer Centers adopted specific procedures both to protect patients and to monitor the possible spread of SARS-CoV-2 among healthcare personnel (HCP). In April 2020 at Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, one of the three oncologic hubs in Lombardy where the Health Regional Authorities referred all the cancer patients of the region, we implemented a prospective longitudinal study aimed at monitoring the serological response to SARS...
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#1Carolina ReduzziH-Index: 6
#2Serena Di CosimoH-Index: 31
Last. Vera CappellettiH-Index: 22
view all 16 authors...
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Abstract Study Objective There are growing concerns on the potential risk of COVID-19 transmission during surgery and in particular during minimally invasive procedure, due to the aerosolization of SARS-CoV-2 particles. However, no study demonstrated this hypothesis. Here, we aimed to investigate the presence SARS-CoV-2 through surgical smoke. Design A prospective pilot study. Setting A third-level cancer center in Northern Italy. Patients Overall, 17 patients had laparoscopic approach for the m...
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#1Serena Di CosimoH-Index: 31
#2Luca PorcuH-Index: 16
Last. Evandro de Azambuja (ULB: Université libre de Bruxelles)H-Index: 60
view all 13 authors...
BACKGROUND Obesity is a risk factor for breast cancer (BC) development, recurrence, and death. In view of this, we aimed to investigate the clinical value of obesity in BC patients treated with anti-HER2 therapies in the NeoALTTO trial, which randomized 455 patients to neo-adjuvant lapatinib, trastuzumab, or their combination plus paclitaxel. METHODS Patients were classified according to their basal body mass index (BMI) into underweight (< 18.5 kg/m2), normal (≥ 18.5; < 25 kg/m2), overweight (≥...
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#1Silvia MartiniH-Index: 3
#2Mariangela FiginiH-Index: 26
Last. Alessandro SattaH-Index: 4
view all 12 authors...
Triple-negative breast cancer (TNBC) is an aggressive disease with poor prognosis and limited therapeutic options. Recent advances in the immunotherapy field have enabled the development of new treatment strategies, among which the use of bispecific antibodies (BsAbs), able to redirect T cells against tumors, has shown promising results. In particular, a BsAb that uses TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) as a target was constructed and demonstrated good results in redirec...
2 CitationsSource
#1Carolina ReduzziH-Index: 6
#2Youbin ZhangH-Index: 2
Last. Massimo CristofanilliH-Index: 100
view all 5 authors...
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In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are limited to EpCAM-enriched CTCs evaluated with the CellSearch. We applied a single-cell protocol allowing identification not only of epithelial CTCs (eCTCs), but also of nonconventiona...
2 CitationsSource
#1Francesca PlatiniH-Index: 5
#2Elisa OrtolanH-Index: 1
Last. Laura D. LocatiH-Index: 31
view all 19 authors...
e18577Background: ATC is a very aggressive disease. In the last years new insights on molecular profile of ATC have led to novel therapeutic options, primarily BRAF-targeted agents. Methods: From M...
1 CitationsSource