Vera Cappelletti
CancerEndocrinologyPathologyOncologyGene expressionReceptorGene expression profilingEstrogenTamoxifenRenal cell carcinomaLiquid biopsyCancer researchBreast cancerCirculating tumor cellCell growthMedicineCell cultureEstrogen receptorBiologyProgesterone receptor
122Publications
20H-index
1,712Citations
Publications 121
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#1Carolina ReduzziH-Index: 5
#2Youbin ZhangH-Index: 2
Last. Massimo CristofanilliH-Index: 76
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In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are limited to EpCAM-enriched CTCs evaluated with the CellSearch. We applied a single-cell protocol allowing identification not only of epithelial CTCs (eCTCs), but also of nonconventiona...
1 CitationsSource
1 CitationsSource
#1S. Di CosimoH-Index: 15
#2Marco SilvestriH-Index: 2
Last. M. G. DaidoneH-Index: 2
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Circulating tumor cells (CTCs) are promising biomarkers for prognosis, therapeutic response prediction, and treatment monitoring in cancer patients. Despite its epithelial origin, renal cell carcinoma (RCC) shows low expression of epithelial markers hindering CTC-enrichment approaches exploiting epithelial cell surface proteins. In 21 blood samples serially collected from 10 patients with metastatic RCC entering the TARIBO trial, we overcame this limitation using the marker-independent Parsortix...
3 CitationsSource
#1Carolina ReduzziH-Index: 5
#2Lorenzo Gerratana (NU: Northwestern University)H-Index: 15
Last. Massimo Cristofanilli (NU: Northwestern University)H-Index: 76
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Background: The prognostic impact of circulating tumor cells (CTCs) in patients with breast cancer is well recognized. Nonetheless, by using the FDA-approved CellSearch™ platform, CTCs are detected only in a fraction of patients, both in early and metastatic breast cancer. Several investigators reported the presence of circulating cells expressing both epithelial and leukocyte markers (dual-positive cells, DPcells) in the blood of patients with breast cancer. In view of the fact that those cells...
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#1Carolina ReduzziH-Index: 5
#2Marta VismaraH-Index: 2
Last. Vera CappellettiH-Index: 20
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Abstract The presence in the blood of patients with solid tumors of circulating cells expressing both epithelial and leukocyte markers (dual-positive cells, DPcells), has often been reported, though it has never been investigated in detail. A recent study suggested that DPcells are hybrid cells derived from the fusion of tumor cells with macrophages. Such fusion hybrids acquire macrophage-associated features endowing them with accelerated growth, increased motility, enhanced invasion activity an...
2 CitationsSource
To determine whether a red clover preparation plus dietary intervention administered to premenopausal women with breast cancer (BC), improves menopausal symptoms due to anti-oestrogen treatment, and hence promotes compliance with tamoxifen, prevents weight gain and is safe. Surgically-treated premenopausal women with oestrogen receptor (ER) positive disease taking tamoxifen were recruited to a prospective double-blind randomized trial (NCT03844685). The red clover group (N = 42) received one ora...
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In metastatic breast cancer the role of circulating tumor cells (CTCs) enumeration for predicting clinical outcome is supported by many studies, most of them dealing with strictly epithelial cells. However, it is becoming clear that CTCs are a heterogeneous cell population characterized by plasticity and including also cells which have lost the epithelial phenotype. Here we review literature data on CTC heterogeneity both at phenotype and at molecular level and discuss the possible contribute of...
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#1Giuseppe ProcopioH-Index: 31
#2Giulia ApollonioH-Index: 2
Last. Elena VerzoniH-Index: 17
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