Integrated analysis of somatic genetic alterations and immune microenvironment in malignant pleural mesothelioma.

e20080 Background: Malignant pleural mesothelioma (MPM) is a rare, aggressive tumor and rapidly fatal when untreated. Advanced high-throughput sequencing technologies allow comprehensive characterization of genetic alterations in tumors. Genomic landscape of MPM is not well understood. Knowledge of immune microenvironment of MPM is critical for developing effective targeted therapies. Methods: We examined biopsies from 12 MPM patients that were...