Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution

Crystallization-driven self assembly (CDSA) was achieved with fully degradable amphiphilic block polymers derived from three natural products, l-lactide, l-cysteine and d-glucose, to afford spherical and cylindrical nanostructures. A series of functional l-cysteine-modified diblock copolymers, poly(l-lactide)-block-poly(α-d-glucose carbonate)s (PLLA-b-PDGC-cys), was synthesized by organocatalyzed sequential ring-opening polymerization (ROP) of...