Abstract Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggestedthat matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to berelated to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discoveredthat the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignantphenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation ofMMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survivalrate of patients with ovarian cancer.Key words: Ovariancancer; Matrix metalloproteinases (MMPs); Tissueinhibitor of metalloproteinases (TIMPs); Invasion; Metastasis Introduction Ovarian cancer is the third most common malignancyof female genitalia, and its etiology is still uncertain. Theincipient symptoms of ovarian cancer are not obvious, andtherefore patients are often in the middle-late stages of thedisease when diagnosed. Moreover, it is dif ficult to thoroughlyremove the tumor mass by surgery. Thus, ovarian canceris refractory and difficult to treat, especially in patients withearly metastasis. Ovarian cancer is the deadliest gyneco-logic tumor and seriously threatens women’s health andlives. Therefore, in order to timely and effectively diagnoseand treat ovarian cancer, as well as to improve the prog-nosis and survival rate of patients, it is essential to identifyovarian cancer-specific tumor markers with high sensitivity.Herein, the latest research progress of matrix metallopro-teinases (MMPs) in ovarian cancer is reviewed.
BACKGROUND: Ovarian cancer is the 5th most common cause of deaths in the women among gynecological tumors. There are many growing evidences that stress and other behavioral factors may affect cancer progression and patient survival. The purpose of this study is to determine the key role of matrix metalloproteinases (MMPs), and cytokines in the aggregation and progression of ovarian cancer. METHODOLOGY: Stress variables (MDA, AGEs, AOPPs, NO), profile of antioxidants (SOD, Catalase, Vitamin E & A...
Background To investigate the expression of MMP-14 and CD44 as well as epithelial-to-mesenchymal transition(EMT)-like changes in ovarian cancer and to determine correlations with clinical outcome.
Though metal-organic frameworks (MOFs) have inspired potential applications in biomedicine, cytotoxicity studies of MOFs have been relatively rare. Here we demonstrate for the first time that an easily available MOF, Fe-MIL-101, possesses intrinsic activity against human SKOV3 ovarian cancer cells and suppress the proliferation of SKOV3 cells (IC50 = 23.6 μg mL−1) and normal mouse embryonic fibroblasts (BABL-3T3, IC50 = 78.3 μg mL−1) cells. It was more effective against SKOV3 cells than typical ...
Last. Fulin Guo(HMU: Harbin Medical University)H-Index: 1
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Background: Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk. Methods: A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (OR...
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for degrading essentially all components of the extracellular matrix (ECM). Accumulating evidence suggests that MMPs might play a critical role in growth, invasion, and metastasis of malignant tumors. A single nucleotide polymorphism (SNP) in the promoter region of MMP-12, MMP-12 82 A/G (rs2276109), has been recognized to play a critical role in regulating the expression of MMP-12, however, its correlation...
Ovarian cancer is the leading cause of the death of all gynecologic tumors.1 Owing to lack of specific and early symptoms as well as effective diagnostic tests, most patients with ovarian cancer present with wide metastatic disease at diagnosis.2 Hence, the prognosis of ovarian cancer is very poor. The 5-year survival rate for patients with ovarian cancer is approximately 44%.3 Several clinicopathological features including International Federation of Gynecology and Obstetrics stage, grade of tu...
Purpose:Zoledronic acid (ZA) is being increasingly recognized for its anti-tumor properties, but the underlying functions are not well understood. In this study, we hypothesized that ZA inhibits ovarian cancer (OC) angiogenesis preventing Rac1 activation. Experimental Design: The biological effects of ZA were examined using a series of in vitro (cell invasion, cytokine production, Rac1 activation, reverse-phase protein array and in vivo (orthotopic mouse models) experiments. Results: There was s...
Catalpol is expected to possess diverse pharmacological actions including anti-cancer, anti-inflammatory and hypoglycemic properties. Matrix metalloproteinase-2 (MMP-2) is closely related to the pathogenesis of ovarian cancer. In addition, microRNA-200 (miR-200) can modulate phenotype, proliferation, infiltration and transfer of various tumors. Here, OVCAR-3 cells were employed to investigate whether the effect of catalpol (25, 50 and 100 μg/mL) promoted apoptosis of ovarian cancer cells and to ...
Cancer is the second-leading cause of death worldwide. Till date, many such effective treatments are available, for example chemotherapy, surgery, and radiation therapy, but there are severe associated side effects, such as increased infection risk, constipation, hair loss, anaemia, among others. Thus, the need for effective therapeutic strategies and screening methodology arises. Researchers around the world are increasingly trying to discover anticancer therapies with as few side effects as po...
Although the molecular pathogenesis of hepatocellular carcinoma (HCC) is uncertain, it is known that the epithelial-mesenchymal transition (EMT) mechanism and epigenetic changes have an important role. This study was focused on evaluating the relationship of 3-Deazaneplanocin A (DZNep) with the EMT mechanism, which is a histone methyltransferase inhibitor on HCC and is also known as an enhancer of zeste homolog 2 (EZH2) inhibitor. Cell viability of HepG2 cells (HCC cell line) assessed for DZNep ...
Proteases play a crucial role in the progression and metastasis of ovarian cancer. Pericellular protein degradation and fragmentation along with remodeling of the extracellular matrix (ECM) is accomplished by numerous proteases that are present in the ovarian tumor microenvironment. Several proteolytic processes have been linked to cancer progression, particularly those facilitated by the matrix metalloproteinase (MMP) family. These proteases have been linked to enhanced migratory ability, extra...
Last. Richard Schulz(U of A: University of Alberta)H-Index: 68
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Matrix metalloproteinases are zinc-dependent endopeptidases that were first discovered as proteases which target and cleave extracellular proteins. During the past twenty years, however, intracellular roles of matrix metalloproteinases were uncovered and research on this new aspect of their biology expanded. Matrix metalloproteinase-2 is the first of this protease family to be reported to play a crucial intracellular role where it cleaves several sarcomeric proteins inside cardiac myocytes durin...
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating gene expression. In most cases, miRNAs interact with the 3' UTRs of target mRNAs to induce their degradation and suppress their translation. Aberrant expression of miRNAs has been detected in EOC tumor...
BACKGROUND: Realgar, a traditional Chinese medicine, has shown antitumor efficacy in several tumor types. We previously showed that realgar nanoparticles (nano-realgar) had significant antileukemia, anti-lung cancer and anti-liver cancer effects. In addition, the anti-tumor effects of nanorealgar were significantly better than those of ordinary realgar. OBJECTIVE: To explore the inhibitory effects and molecular mechanisms of nano-realgar on the migration, invasion and metastasis of mouse breast ...
Last. Dong-Wan Seo(DU: Dankook University)H-Index: 22
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In this study, we investigated the effects and molecular mechanisms of 2-phenylbenzimidazole-5-sulphonic acid (PBSA), an ultraviolet B protecting agent used in sunscreen lotions and moisturizers, on ovarian cancer cell responses and tumour angiogenesis. PBSA treatment markedly blocked mitogen-induced invasion through down-regulation of matrix metalloproteinase (MMP) expression and activity in ovarian cancer SKOV-3 cells. In addition, PBSA inhibited mitogen-induced cell proliferation by suppressi...
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy resulting in high mortality. HCC progression is associated with abnormal signal transduction that changes cell signaling pathways and ultimately leads to dysregulation of cell functions and uncontrolled cell proliferation. Present study was undertaken with the objective to identify differentially expressed proteins and quantify their transcript expression in the liver of HCC-bearing rats vis-a-vis controls and to decipher...
#1Xue Guan(PRC: China Medical University (PRC))H-Index: 10
#2Zhi-Hong Zong(PRC: China Medical University (PRC))H-Index: 16
Last. Yang Zhao(PRC: China Medical University (PRC))H-Index: 24
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Abstract Circular RNAs (circRNAs) have been reported to participate in the molecular mechanism of human cancers. The PUM1 gene has been confirmed to be closely related to tumorigenesis and progression of ovarian cancer. In the present study, we explored the function and underlying molecular mechanism of circPUM1 in ovarian cancer. RT-qPCR analysis showed upregulation of circPUM1 in ovarian cancer tissues compared with normal ovaries. Gain- and loss-of-function experiments indicated that circPUM1...