Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer.

Published on May 18, 2017in Brazilian Journal of Medical and Biological Research2.023
· DOI :10.1590/1414-431X20176104
Y. Zhang1
Estimated H-index: 1
(NCU: Nanchang University),
Q. Chen1
Estimated H-index: 1
(NCU: Nanchang University)
Abstract Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggestedthat matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to berelated to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discoveredthat the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignantphenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer. The investigation ofMMP mechanism in ovarian cancer will facilitate the development of effective anti-tumor drugs, and thereby improve the survivalrate of patients with ovarian cancer.Key words: Ovariancancer; Matrix metalloproteinases (MMPs); Tissueinhibitor of metalloproteinases (TIMPs); Invasion; Metastasis Introduction Ovarian cancer is the third most common malignancyof female genitalia, and its etiology is still uncertain. Theincipient symptoms of ovarian cancer are not obvious, andtherefore patients are often in the middle-late stages of thedisease when diagnosed. Moreover, it is dif ficult to thoroughlyremove the tumor mass by surgery. Thus, ovarian canceris refractory and difficult to treat, especially in patients withearly metastasis. Ovarian cancer is the deadliest gyneco-logic tumor and seriously threatens women’s health andlives. Therefore, in order to timely and effectively diagnoseand treat ovarian cancer, as well as to improve the prog-nosis and survival rate of patients, it is essential to identifyovarian cancer-specific tumor markers with high sensitivity.Herein, the latest research progress of matrix metallopro-teinases (MMPs) in ovarian cancer is reviewed.
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