Brazilian Journal of Medical and Biological Research
Papers 6920
1 page of 692 pages (6,920 results)
#1Lucas Delmonico (UFRJ: Federal University of Rio de Janeiro)H-Index: 4
Last. Marcia V. FournierH-Index: 10
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Clinically relevant biomarkers are useful to determine cancer patients' prognosis and treatments. To discover new putative biomarkers, we performed in silico analysis of a 325-gene panel previously associated with breast epithelial cell biology and clinical outcomes. Sixteen public datasets of microarray samples representing 8 cancer types and a total of 3,663 patients' samples were used for the analyses. Feature selection was used to identify the best subsets of the 325 genes for each classific...
Genomic studies have provided insights into molecular subgroups and oncogenic drivers of pediatric brain tumors (PBT) that may lead to novel therapeutic strategies. Participants of the cohort Pediatric Brain Tumor Atlas: CBTTC (CBTTC cohort), were randomly divided into training and validation cohorts. In the training cohort, Kaplan-Meier analysis and univariate Cox regression model were applied to preliminary screening of prognostic genes. The LASSO Cox regression model was implemented to build ...
Sevoflurane (SEVO) is widely applied as an anesthetic, which exerts antitumor capacity in various cancers, including hepatocellular carcinoma (HCC). Previous studies indicated that long non-coding RNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) was upregulated, while microRNA-29a-3p (miR-29a-3p) was downregulated in HCC. Thus, we aimed to explore the roles of KCNQ1OT1 and miR-29a-3p in HCC cells exposed to SEVO. Cell proliferation, apoptosis, migration, and invasion were assessed by ...
#1Y D Sun (SJTU: Shanghai Jiao Tong University)
#2Y S Gao (SJTU: Shanghai Jiao Tong University)
Last. Q F Li (SJTU: Shanghai Jiao Tong University)
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Ischemia-reperfusion injury (IRI) has brought attention to flap failure in reconstructive surgery. To improve the prognosis of skin transplantation, we performed experimental IRI by surgical obstruction of blood flow and used sodium ferulate (SF) to prevent IRI in rats. After SF treatment, the morphological and histological changes of the skin flaps were observed by H&E and Masson's trichrome staining. We also detected the expression levels of COX-1, HO-1, and Ki67 by immunohistochemical and wes...
#1Luong Thi My Ngan (Ho Chi Minh City University of Science)H-Index: 1
#2M.T. Tan (Ho Chi Minh City University of Science)
Last. T.T. Hieu (Ho Chi Minh City University of Science)
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Utilization of plant resources for treatment of Helicobacter pylori infections is one of the appealing approaches as rapid emergence of antibiotic-resistant strains is occurring throughout the world. Ethanol extract and its fractions from Hibiscus rosa-sinensis red flower were assessed for antibacterial and urease inhibitory activities towards forty-three clinical strains and two reference strains of H. pylori. The ethyl acetate fraction exhibited the most potent bacteriostatic activity with min...
#1Glauciane Garcia de Figueiredo (USP: University of São Paulo)H-Index: 10
Last. Victor Hugo Aquino (USP: University of São Paulo)H-Index: 22
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Dengue is the most important arthropod-borne viral disease worldwide. Infection with any of the four dengue virus (DENV) serotypes can be asymptomatic or lead to disease with clinical symptoms ranging from undifferentiated and self-limiting fever to severe dengue disease, which can be fatal in some cases. Currently, no specific antiviral compound is available for treating DENV. The aim of this study was to identify compounds in plants from Paraguayan folk medicine with inhibitory effects against...
#1Diane Duarte Hartmann (UFSM: Universidade Federal de Santa Maria)H-Index: 5
#2Rodrigo Pereira Martins (UFSM: Universidade Federal de Santa Maria)H-Index: 2
Last. Gustavo Orione Puntel (UFSM: Universidade Federal de Santa Maria)H-Index: 15
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The skin injury healing process involves the main phases of homoeostasis, inflammation, proliferation, and remodeling. The present study aimed to analyze the effects of low-level laser therapy (LLLT) on hematological dynamics, oxidative stress markers, and its relation with tissue healing following skin injury. Wistar rats were divided into control, sham, skin injury, and skin injury LLLT. The biochemical and morphological analyses were performed in the inflammatory (1 and 3 days) and regenerati...
#1Dongxue Wang (Harbin University of Commerce)
#2Ying Zhao (Harbin University of Commerce)H-Index: 2
Last. Hailong Xie (Heilongjiang University of Chinese Medicine)H-Index: 2
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The objective of this study was to examine the safety of multiple repeated percutaneous punctures of cisterna magna for collecting cerebrospinal fluid (CSF) and preliminarily determine the optimal time interval and volume at each collection. Sixty Wistar rats were randomly assigned to six groups: 10 d-0 μL, 10 d-100 μL (100 μL CSF collected at an interval of 10 days), 10 d-150 μL, 15 d-0 μL, 15 d-100 μL, and 15 d-150 μL. CSF was collected by percutaneous puncture of the cisterna magna at four ti...
#1C. G. M. SantosH-Index: 1
Last. R. Silva (UFRJ: Federal University of Rio de Janeiro)
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Physical performance is a multifactorial and complex trait influenced by environmental and hereditary factors. Environmental factors alone have been insufficient to characterize all outstanding phenotypes. Recent advances in genomic technologies have enabled the investigation of whole nuclear and mitochondrial genome sequences, increasing our ability to understand interindividual variability in physical performance. Our objective was to evaluate the association of mitochondrial polymorphic loci ...
#1Marcele Stephanie de Souza Buto (UFSCar: Federal University of São Carlos)H-Index: 4
#2Verena Vassimon-Barroso (UFSCar: Federal University of São Carlos)H-Index: 4
Last. Anielle Cristhine de Medeiros Takahashi (UFSCar: Federal University of São Carlos)H-Index: 8
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The aim of this study was to investigate the effects of multicomponent training on baroreflex sensitivity (BRS) and heart rate (HR) complexity of prefrail older adults. Twenty-one prefrail community-dwelling older adults were randomized and divided into multicomponent training intervention group (MulTI) and control group (CG). MulTI performed multicomponent exercise training over 16 weeks and CG was oriented to follow their own daily activities. The RR interval (RRi) and blood pressure (BP) seri...
Top fields of study
Diabetes mellitus