Preparation and characterization of mucosal adhesive and two-step drug releasing cetirizine-chitosan nanoparticle
Abstract
To develop a functional nanosized mucosal drug delivery system, a series of amphiphilic cetirizine-chitosan polymer (CTZ-CSs) were constructed. CTZ-CSs could self-assemble into nanoparticles (NPs) which gradually evolved from irregular aggregates to spherical particles with an increasing substitution degree (DS) in CTZ group. The average particle size of CTZ-CSs-NPs with nano ZS90 Zetasizer varied from 153.92 nm to 184.48 nm and their zeta...
Paper Details
Title
Preparation and characterization of mucosal adhesive and two-step drug releasing cetirizine-chitosan nanoparticle
Published Date
Oct 1, 2017
Journal
Volume
173
Pages
600 - 609
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Notes
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