PGBD5 promotes site-specific oncogenic mutations in human tumors
Abstract
Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors. These rearrangements involved PGBD5-specific signal (PSS)...
Paper Details
Title
PGBD5 promotes site-specific oncogenic mutations in human tumors
Published Date
May 15, 2017
Journal
Volume
49
Issue
7
Pages
1005 - 1014
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