Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
Abstract
The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combined complex genetic analyses, biochemical studies and pharmacological interference to demonstrate a central role of Ptpn11 in postnatal myogenesis of...
Paper Details
Title
Loss of Ptpn11 (Shp2) drives satellite cells into quiescence
Published Date
May 2, 2017
Journal
Volume
6
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