Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands

Significance Death-driven compensatory proliferation to repair tissue defects is an important promoter of inflammation-associated carcinogenesis. Our work using a mouse model demonstrates that a biliary epithelial injury-induced regenerative response mediated by IL-33 accelerates development of extrahepatic cholangiocarcinoma (ECC) from peribiliary glands, an effect that was suppressed by anti–IL-33 treatment. Thus, IL-33 is a potential...