Kazuhiko Koike
University of Tokyo
CancerInternal medicineRadiologyEndocrinologySurgeryPathologyOncologyVirologyRetrospective cohort studyImmunologyHepatitis C virusHepatocellular carcinomaStentPancreatic cancerHepatologyCancer researchCarcinogenesisMedicineBiologyGastroenterology
Publications 1434
#1Yousuke Nakai (UTokyo: University of Tokyo)H-Index: 51
#2Tsuyoshi Hamada (UTokyo: University of Tokyo)H-Index: 38
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
view all 11 authors...
#1Ryota Niikura (UTokyo: University of Tokyo)H-Index: 25
#2Tomonori Aoki (UTokyo: University of Tokyo)H-Index: 19
Last. Masanori Ochi (UTokyo: University of Tokyo)H-Index: 1
view all 14 authors...
Introduction and aims: To compare endoscopy gastric cancer images diagnosis rate between artificial intelligence (AI) and expert endoscopists. Patients and methods: We used the retrospective data of 500 patients, including 100 with gastric cancer, matched 1:1 to diagnosis by AI or expert endoscopists. We retrospectively evaluated the non-inferiority (prespecified margin 5%) of the per-patient rate of gastric cancer diagnosis by AI and compared the per-image rate of gastric cancer diagnosis. Resu...
#1Genso Notoya (UTokyo: University of Tokyo)
#2Ryota Niikura (UTokyo: University of Tokyo)H-Index: 25
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
view all 6 authors...
Heyde's syndrome, which is caused by aortic stenosis and subsequent acquired von Willebrand factor deficiency, is a gastrointestinal bleeding disease. Gastrointestinal bleeding develops in patients with Heyde's syndrome, which may have a different prognosis from general gastrointestinal bleeding; thus, it is important to understand the clinical course. We report a 76-year-old Japanese female who underwent aortic mechanical valve replacement 1 year ago and presented with recurrent gastrointestina...
#1Yuko Miura (UTokyo: University of Tokyo)
#2Yosuke Tsuji (UTokyo: University of Tokyo)H-Index: 20
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
view all 10 authors...
Recently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protective effect of a novel ulcer coating material, whose physical properties can be easily controlled and designed. We applied the novel injectable hydrogel to artificial ulcers induced on the gastric mucosa of rats....
#1Ryo Kurokawa (UTokyo: University of Tokyo)H-Index: 3
#2Shohei Inui (UTokyo: University of Tokyo)H-Index: 3
Last. Kazunaga Ishigaki (UTokyo: University of Tokyo)H-Index: 10
view all 13 authors...
In this single-center retrospective study, we intended to evaluate the frequencies and characteristics of computed tomography findings of pancreatobiliary inflammation (PBI) in patients treated with lenvatinib and the relationship of these findings with treatment-planning changes. We included 78 patients (mean ± standard deviation, 69.8 ± 9.4 years, range: 39–84 years, 62 men) with hepatocellular carcinoma (n = 62) or thyroid carcinoma (n = 16) who received lenvatinib (June 2016–September 2020)....
#1Makoto SanoH-Index: 13
#2Ryota Takahashi (UTokyo: University of Tokyo)H-Index: 25
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
view all 23 authors...
Objective Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC using a genetically engineered mouse model, PKF (Ptf1acre/+;LSL-KrasG12D/+;Tgfbr2flox/flox). Design Presence of CAT in PKF mice was detected by systemic autopsy. Plasma cytokines we...
6 CitationsSource
#1Yuki HiroseH-Index: 12
#2Akiyoshi Kinoshita (Jikei University School of Medicine)H-Index: 9
Last. Masayuki Saruta (Jikei University School of Medicine)H-Index: 20
view all 5 authors...
#1Kazuma Sekiba (Japan Society for the Promotion of Science)H-Index: 6
#2Motoyuki Otsuka (UTokyo: University of Tokyo)H-Index: 45
Last. Kei Miyakawa (YCU: Yokohama City University)H-Index: 9
view all 12 authors...
Background & Aims null HBV causes hepatocellular carcinoma (HCC). While it was recently shown that the ability of HBV X protein (HBx) to impair the Smc5/6 (structural maintenance of chromosome 5/6) complex is important for viral transcription, HBx is also a potent driver of HCC. However, the mechanism by which HBx expression induces hepatocarcinogenesis is unclear. null null null Methods null Degradation of the Smc5/6 complex and accumulation of DNA damage were observed in both in vivo and in vi...
#1Takuma Nakatsuka (UTokyo: University of Tokyo)H-Index: 8
#2Ryosuke Tateishi (UTokyo: University of Tokyo)H-Index: 53
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
view all 3 authors...
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, affecting approximately 25% of the world's population. Recently, because of the sedentary lifestyle and overnutrition resulting from urbanisation, the burden of NAFLD has rapidly increased in many Asian countries. Currently, the prevalence of NAFLD in Asia is approximately 30%, as is the case in many Western countries. In Asia, the prevalence and presentation of NAFLD vary widely across regions becau...