Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex

Volume: 114, Issue: 21, Pages: 5431 - 5436
Published: Apr 10, 2017
Abstract
The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and mediates broad responses to numerous environmental pollutants and cellular metabolites, modulating diverse biological processes from adaptive metabolism, acute toxicity, to normal physiology of vascular and immune systems. The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin...
Paper Details
Title
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex
Published Date
Apr 10, 2017
Volume
114
Issue
21
Pages
5431 - 5436
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