Dnmt3a regulates T-cell development and suppresses T-ALL transformation

Volume: 31, Issue: 11, Pages: 2479 - 2490
Published: Mar 21, 2017
Abstract
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises ~15% and 25% of pediatric and adult ALL cases, respectively. It is well-established that activating NOTCH1 mutations are the major genetic lesions driving T-ALL in most patients, but efforts to develop targeted therapies against this pathway have produced limited success in...
Paper Details
Title
Dnmt3a regulates T-cell development and suppresses T-ALL transformation
Published Date
Mar 21, 2017
Journal
Volume
31
Issue
11
Pages
2479 - 2490
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