Characterization of membranes based on cellulose acetate butyrate/poly(caprolactone)triol/doxycycline and their potential for guided bone regeneration application.
This paper discusses the feasibility of using membranes based on cellulose acetate butyrate/poly(caprolactone)triol loaded with doxycycline for guided bone regeneration. Those membranes were obtained by solvent casting varying the cellulose acetate butyrate: poly(caprolactone)triol:doxycycline (CAB:PCL-T:DOX) mass ratios and characterized by scanning electron microscopy, differential scanning calorimetry, dynamical mechanical analysis, swelling and weight loss, drug release, in vitro antimicrobial activity and in vivo inflammatory response. Neat CAB and CAB:PCL-T:DOX membranes exhibited inner porous structure, which has a pore-size reduced with increasing of the PCL-T ratio. DSC results demonstrated that the molecular dispersion of the DOX into the CAB:PCL-T membrane was conditioned by PCL-T amount. Elastic modulus reduced noticeably with increased of the PCL-T ratio in the membrane from 2 to 3, while the strain at failure showed an increase of ca. 10-fold on the same condition. The DOX release mechanism from the membranes was found to be Fickian or quasi-Fickian diffusion. Membranes assessed immediately after the preparation, and even as the membranes immersed in synthetic saliva during 7 days, demonstrated significant inhibition in the growth of Staphylococcus aureus and Escherichia coli. Subcutaneous implant test on rat in vivo showed that the CAB:PCL-T:DOX membrane (7:3:1) did not trigger chronic inflammatory responses. These results suggest the feasibility in applying the CAB:PCL-T:DOX membrane as a barrier for guided bone regeneration.
Polymer composites exhibit very high strength but this is usually found to be at the expense of toughness, which greatly limits their application in many fields. Inspired by the hierarchical architectures in spider silk, we attempted to combine simultaneous high strength and toughness via a hydrogen bonding network. PVA composites with tannic acid (TA) molecules were fabricated by a green and easy-to-scale-up water casting method. The results showed that the hydrogen bonding crosslinking between...
Last. Junchao Wei(NCU: Nanchang University)H-Index: 20
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Polymer membranes have been widely used in guided tissue regeneration (GTR) and guided bone regeneration (GBR). In this review, various commercially available membranes are described. Much attention is paid to the recent development of biodegradable polymers applied in GTR and GBR, and the important issues of biodegradable polymeric membranes, including their classification, latest experimental research and clinical applications, as well as their main challenges are addressed. Herein, natural po...
Last. Quanchang Tan(Fourth Military Medical University)H-Index: 2
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Abstract Guided tissue regeneration (GTR) membranes are key materials used to create barriers between soft and bone tissues during bone defect repair; however, single-function barrier GTR membranes cannot meet clinical requirements. In this paper, we propose a GTR membrane with drug release, bone guidance, and barrier functions; this membrane is a poly(lactic- co -glycolic acid) (PLGA)/hydroxyapatite (HA) (core)-collagen/amoxicillin (shell) nanofiber membrane fabricated by coaxial electrospinnin...
#1Haiping Lu(ZJNU: Zhejiang Chinese Medical University)H-Index: 4
#2Yi Liu(Academic Center for Dentistry Amsterdam)H-Index: 6
Last. Gang Wu(Academic Center for Dentistry Amsterdam)H-Index: 23
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The repair of infected bone defects is still challenging in the fields of orthopedics, oral implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone tissue can be significantly compromised by the large size of bone defects and the potential/active bacterial activity. Infected bone defects are conventionally treated by a systemic/local administration of antibiotics to control infection and a subsequent implantation of bone grafts, such as autografts and allografts...
Abstract Background The effects of systemic antibiotics on controlling infective pathogens after guided bone regeneration(GBR) procedures especially in membrane exposures are limited. However, local administrations of antibiotics are rare in GBR techniques. Aim The aim of this study was to investigate the osteogenesis potential and the antibacterial effect of a doxycycline releasing collagen membrane in surgically created and contaminated defects in rat tibiae. Material and methods Defects were ...
The aim of this study was to determine the optimal sterilization procedure for biodegradable polyester-based guided bone regeneration membranes. The effects of sterilization using low-temperature hydrogen peroxide gas plasma, 75% ethanol (EtOH; two soaking times), and ultraviolet radiation on the structure and biological properties of electrospun poly(e-caprolactone) membranes were investigated. The results demonstrated that all were effective sterilization methods. The membranes were then asses...
Last. Makoto Otsuka(Musashino University)H-Index: 56
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OBJECTIVES: The aim of this study was to investigate the bone regenerative properties of a heat treated cross-linked GBR membrane with zinc hydroxyapatite powders in the rat calvarial defect model over a 6-week period. MATERIAL AND METHODS: In vitro physio-chemical characterization involved X-ray diffraction analysis, surface topology by scanning electron microscopy, and zinc release studies in physiological buffers. Bilateral rat calvarial defects were used to compare the Zn-HAp membranes again...
Mixed-ligand Cu(II) complexes of the type [Cu(doxycycline)(L)(H2O)2](NO3)2, where doxycycline = [4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide] and L = 2,2′-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq, 3) and dipyrido[3,2-a:2′,3′-c]phenazine (dppz, 4) have been synthesised and characterised by structural, analytical, and spectral methods. The single-crystal X-ray structures of...
Last. Gopinath Mani(USD: University of South Dakota)H-Index: 18
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Abstract Drug-coated balloons (DCBs) are used to treat various cardiovascular diseases. Currently available DCBs carry drug on the balloon surface either solely or using different carriers. Several studies have shown that a significant amount of drug is lost in the blood stream during balloon tracking to deliver only a sub-therapeutic level of drug at the treatment site. This research is focused on developing paclitaxel (PAT) loaded polyethylene oxide (PEO) films (PAT–PEO) as a controlled drug d...
Last. Mansour Siavosh(IUMS: Isfahan University of Medical Sciences)
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BACKGROUND The objective of the present study was co-delivery of venlafaxin (VEN) and doxycycline (DOX), a matrix metalloproteinase inhibitor drug, for alleviating inflammation and neuropathy in diabetic foot ulcer (DFU). METHODS Bacterial cellulose nanofiber sheets (BCNS) were loaded with DOX and VEN and categorized by their loading efficiency, release profiles and ex vivo permeation throughrat skin. The optimized nanofibers were used in patients with DFU to compare with the standard wound care...
Abstract The mechanical properties and structural stability of hydrogels and their performance in antidegradation can be enhanced by cross-linking them with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC). However, residual EDC compromises the biocompatibility of cross-linked hydrogels and the formability of un-cross-linked hydrogels. In this study, a facile process for preparing hydrogel regenerative membranes exerting antibacterial effects and containing gelatin/hyaluronic a...
Last. Eman A. Fadl(Alexandria University)H-Index: 2
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The most common reverse osmosis (RO) membranes that achieved economic water desalination applications are made of cellulose acetate (CA). Cellulose acetate propionate (CAP) and cellulose acetate butyrate (CAB) have been blended with CA as innovative combinations to produce RO membranes through phase inversion technique. The relation between membranes compositions, structure, morphology, hydrophilicity and applicability were examined. Scanning electron microscope and Fourier transform infrared we...
Abstract Polymer-based wafers containing gold nanoparticles (AuNP) were prepared using κ-carrageenan (κC), locust bean gum (LBG) and polyvinyl alcohol (PVA) at ratios of 42/22/13% w/w and 35/15/17% w/w. The synthesized AuNPs were evaluated for their particle size and morphology. The produced wafers containing AuNPs were investigated for their physicochemical, morphological, mechanical, and swelling properties. In addition, bacterial barrier activity and in vitro cytotoxicity were also evaluated ...
The bacterial colonization of absorbable membranes used for Guided Tissue Regeneration (GTR) as well as their rapid degradation that can cause their rupture, are considered the major reasons of clinical failure. To address this, composite membranes of polycaprolactone (PCL) and gelatin (Gel) loaded with ZnO-NPs (1, 3 and 6 w% relative to PCL content) were fabricated by electrospinning. To fabricate homogeneous fibrillar membranes, acetic acid was used as a sole common solvent to enhance the misc...
Last. Gul Shahnaz(QAU: Quaid-i-Azam University)H-Index: 22
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Localized intra-pocket, retentive, biodegradable, prolonged release thiolated membrane can provide an improved therapeutic efficacy of doxycycline at the site of action with evading off target side effects. To this end, thiolated chitosan-hyaluronic acid composite polymeric complex next-generation of the periodontal membrane was manufactured by solvent casting method. FTIR spectroscopic analysis displayed successful immobilization of thiol groups on the manufactured thiolated periodontal membran...
Last. Xiuyin Zhang(SJTU: Shanghai Jiao Tong University)H-Index: 4
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Abstract Guided bone regeneration (GBR) membranes have the potential to prevent the invasion of epithelial and connective tissues as well as to maintain a stable space for facilitating the ingrowth of regenerative bone tissue. However, the bioactivity and regeneration potential of currently available membranes still need to be improved. In this study, a novel bi-layered membrane with both osteogenic and antibacterial functions was developed for GBR applications. The loose layer (LL) of the membr...
Corrosion occurs due to the oxidation and reduction reactions between the material and its environment. The oxidation reaction defined as reactions that produce electrons and reduction is between two elements that bind the electrons. Corrosion cannot be inevitable in life both within the industry and household. Corrosion cannot eliminate but can be control. According to the voltaic table, Aluminum is a metal that easily corroded. This study attempts to characterize the type of corrosion by using...