Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma

Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct subtypes of non–small-cell lung carcinoma. Interestingly, approximately 4% to 9% of human non–small-cell lung carcinoma tumors contain mixed adenomatous and squamous pathologies in a single lesion, clinically termed adenosquamous cell carcinoma. More important, these two different pathological components frequently share identical oncogenic mutations, indicative of a...